Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 4/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.65 |
| ▸ | KDM1A | O60341 | 1/20 | 0.65 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.65 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.65 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.65 |
| ▸ | CCNA2 | P20248 | 3/20 | 0.40 |
| ▸ | CDK2 | P24941 | 3/20 | 0.40 |
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.38 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.38 |
| ▸ | NAMPT | P43490 | 1/20 | 0.37 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.37 |
| ▸ | EP300 | Q09472 | 2/20 | 0.37 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.37 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.36 |
| ▸ | CCNC | P24863 | 2/20 | 0.35 |
| ▸ | CDK8 | P49336 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 1/20 | 0.35 |
| ▸ | CA2 | P00918 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21462830 | 1.00 | HDAC1 (0.65) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Hydrochloric Acid SCHEMBL3434610 | 0.99 | HDAC1 (0.64) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Hydrochloric Acid SCHEMBL3434603 | 0.99 | HDAC1 (0.64) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| SCHEMBL1613971 | 0.81 | HDAC3 (0.61) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Domatinostat SCHEMBL30477018 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Domatinostat SCHEMBL1613943 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Domatinostat SCHEMBL1613939 | 0.79 | HDAC1 (1.00) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Domatinostat SCHEMBL1614665 | 0.78 | HDAC1 (0.98) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Domatinostat SCHEMBL1613921 | 0.78 | HDAC1 (0.98) | HDAC1HDAC3HDAC2KDM1AHDAC10 | |
| Domatinostat SCHEMBL1614634 | 0.78 | HDAC1 (0.98) | HDAC1HDAC3HDAC2KDM1AHDAC10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781557-A1 | PHARMACEUTICAL COMBINATION PRODUCTS COMPRISING A HISTONE DEACETYLASE (HDAC) INHIBITOR AND A TLR7 AGONIST AND/OR TLR8 AGONIST FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019197682-A1 | PHARMACEUTICAL COMBINATION PRODUCTS COMPRISING A HISTONE DEACETYLASE (HDAC) INHIBITOR AND A TLR7 AGONIST AND/OR TLR8 AGONIST FOR THE TREATMENT OF CANCER | 4SC AG (DE) | 2019-10-17 | — | — | WO | disclosed |