Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H2 | P55055 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.33 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.33 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.33 |
| ▸ | CHRM3 | P20309 | 1/20 | 0.33 |
| ▸ | GPR119 | Q8TDV5 | 2/20 | 0.32 |
| ▸ | RORC | P51449 | 2/20 | 0.32 |
| ▸ | DDB1 | Q16531 | 1/20 | 0.32 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.32 |
| ▸ | USP2 | O75604 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
| ▸ | UCHL1 | P09936 | 1/20 | 0.30 |
| ▸ | PREP | P48147 | 1/20 | 0.30 |
| ▸ | HPGD | P15428 | 1/20 | 0.30 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.30 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.30 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18321103 | 1.00 | NR1H2 (0.36) | NR1H2EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL23942085 | 1.00 | NR1H2 (0.36) | NR1H2EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL1268620 | 0.83 | NR1H2 (0.33) | NR1H2EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL28626040 | 0.83 | NR1H2 (0.39) | NR1H2EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL25698825 | 0.83 | NR1H2 (0.36) | NR1H2EPHX2CHRM2CHRM1CHRM3 | |
| SCHEMBL29069175 | 0.82 | PPM1D (0.36) | NR1H2USP2SMN1; SMN2 | |
| SCHEMBL377199 | 0.82 | PPM1D (0.36) | NR1H2USP2SMN1; SMN2 | |
| SCHEMBL31105174 | 0.82 | PPM1D (0.36) | NR1H2USP2SMN1; SMN2 | |
| SCHEMBL29039966 | 0.82 | PPM1D (0.36) | NR1H2USP2SMN1; SMN2 | |
| SCHEMBL29039969 | 0.82 | PPM1D (0.36) | NR1H2USP2SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |