Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.77 |
| ▸ | JAK2 | O60674 | 1/20 | 0.65 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.65 |
| ▸ | ROS1 | P08922 | 1/20 | 0.65 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.65 |
| ▸ | FLT3 | P36888 | 1/20 | 0.65 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.65 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.65 |
| ▸ | BTK | Q06187 | 1/20 | 0.65 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.65 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.65 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478682 | 0.88 | SYK (0.82) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2480034 | 0.87 | SYK (1.00) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2479228 | 0.86 | SYK (1.00) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL21471529 | 0.86 | SYK (0.81) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2480610 | 0.86 | SYK (0.84) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL15308150 | 0.84 | SYK (0.81) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2479139 | 0.84 | SYK (0.81) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2481177 | 0.84 | SYK (0.77) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2479094 | 0.84 | SYK (1.00) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2899108 | 0.84 | SYK (0.77) | SYKJAK2NTRK1ROS1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3553065-A1 | HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR | Hangzhou Innogate Pharma Co., Ltd. (CN) | 2019-10-16 | — | — | EP | disclosed |