Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DBH | P09172 | 3/20 | 0.45 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.44 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.44 |
| ▸ | HDAC8 | Q9BY41 | 2/20 | 0.44 |
| ▸ | PTPN5 | P54829 | 4/20 | 0.43 |
| ▸ | PTGDR2 | Q9Y5Y4 | 1/20 | 0.42 |
| ▸ | PTPN2 | P17706 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.39 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.38 |
| ▸ | CEL | P19835 | 2/20 | 0.38 |
| ▸ | MEN1 | O00255 | 2/20 | 0.38 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.38 |
| ▸ | PTPN1 | P18031 | 1/20 | 0.37 |
| ▸ | MMP2 | P08253 | 1/20 | 0.37 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.37 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21471570 | 0.98 | PTGDR2 (0.45) | DBHHDAC4HDAC2HDAC8PTPN5 | |
| SCHEMBL23433018 | 0.86 | HDAC4 (0.56) | DBHHDAC4HDAC2HDAC8PTPN5 | |
| SCHEMBL23250689 | 0.83 | DBH (0.41) | DBHHDAC4HDAC2HDAC8HDAC6 | |
| SCHEMBL23433216 | 0.82 | PTPN5 (0.38) | DBHHDAC4HDAC2HDAC8PTPN5 | |
| SCHEMBL4960831 | 0.81 | PTPN5 (0.44) | HDAC4HDAC2HDAC8PTPN5PTGDR2 | |
| SCHEMBL4958862 | 0.79 | PTPN5 (0.46) | HDAC4HDAC2HDAC8PTPN5PTGDR2 | |
| SCHEMBL4958978 | 0.79 | PTPN5 (0.46) | HDAC4HDAC2HDAC8PTPN5PTGDR2 | |
| SCHEMBL201425 | 0.79 | PTPN5 (0.46) | HDAC4HDAC2HDAC8PTPN5PTGDR2 | |
| SCHEMBL4959318 | 0.79 | PTPN5 (0.46) | HDAC4HDAC2HDAC8PTPN5PTGDR2 | |
| SCHEMBL4960398 | 0.79 | PTPN5 (0.46) | HDAC4HDAC2HDAC8PTPN5PTGDR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2024073131-A2 | METHOD OF TREATING NEURODEGENERATIVE DISEASES | THE BOARD OF TRUSTEES OF THE UNIVESITY OF ILLINOIS (US) | 2024-04-04 | — | — | WO | disclosed |
| WO-2019200314-A2 | HINOKITIOL ANALOGUES, METHODS OF PREPARING AND PHARMACEUTICAL COMPOSITIONS THEREOF | THE BOARD OF TRUSTEES OF THE UNIVERSITY OF ILLINOIS (US) | 2019-10-17 | — | — | WO | disclosed |