Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 1/20 | 0.42 |
| ▸ | SYK | P43405 | 13/20 | 0.42 |
| ▸ | CD63 | P08962 | 5/20 | 0.41 |
| ▸ | CDK4 | P11802 | 1/20 | 0.40 |
| ▸ | CCND3 | P30281 | 1/20 | 0.40 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.40 |
| ▸ | JAK2 | O60674 | 3/20 | 0.39 |
| ▸ | JAK1 | P23458 | 1/20 | 0.39 |
| ▸ | JAK3 | P52333 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL24179240 | 0.81 | SYK (0.70) | SYKJAK2 | |
| SCHEMBL30806184 | 0.81 | SYK (0.43) | AURKASYKCD63JAK2MAPT | |
| SCHEMBL2217499 | 0.80 | CCND3 (0.51) | AURKASYKCD63CDK4CCND3 | |
| SCHEMBL23911878 | 0.79 | SYK (0.70) | SYKJAK2 | |
| SCHEMBL21471429 | 0.78 | AURKA (0.53) | AURKASYKCD63JAK2 | |
| SCHEMBL30806172 | 0.77 | AURKA (0.45) | AURKASYKCD63HDAC1JAK2 | |
| SCHEMBL15551735 | 0.77 | SYK (0.65) | AURKASYKCD63CDK4JAK2 | |
| SCHEMBL19998666 | 0.76 | AURKA (0.53) | AURKASYKCD63JAK2 | |
| SCHEMBL20005722 | 0.75 | AURKA (0.65) | AURKASYKCD63JAK2 | |
| SCHEMBL1542681 | 0.74 | PDGFRB (0.44) | AURKASYKJAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3553065-A1 | HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR | Hangzhou Innogate Pharma Co., Ltd. (CN) | 2019-10-16 | — | — | EP | disclosed |