Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 4/20 | 0.63 |
| ▸ | SYK | P43405 | 16/20 | 0.59 |
| ▸ | CD63 | P08962 | 2/20 | 0.59 |
| ▸ | JAK2 | O60674 | 1/20 | 0.56 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.56 |
| ▸ | ROS1 | P08922 | 1/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | FLT3 | P36888 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.56 |
| ▸ | BTK | Q06187 | 1/20 | 0.56 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.56 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21471538 | 0.90 | AURKA (0.66) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL23911841 | 0.88 | AURKA (0.70) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL21471537 | 0.86 | AURKA (0.73) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL21471531 | 0.85 | AURKA (0.66) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL23911842 | 0.85 | AURKA (0.63) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL4336940 | 0.84 | SYK (0.68) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL23911844 | 0.84 | AURKA (0.58) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL3795040 | 0.84 | AURKA (0.64) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL24864097 | 0.83 | SYK (0.79) | AURKASYKCD63JAK2NTRK1 | |
| SCHEMBL2482747 | 0.82 | AURKA (0.77) | AURKASYKCD63JAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3553065-A1 | HETEROCYCLIC COMPOUND AS SYK INHIBITOR AND/OR SYK-HDAC DUAL INHIBITOR | Hangzhou Innogate Pharma Co., Ltd. (CN) | 2019-10-16 | — | — | EP | disclosed |