Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 20/20 | 0.64 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.43 |
| ▸ | FLT3 | P36888 | 1/20 | 0.43 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.43 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | BTK | Q06187 | 1/20 | 0.43 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.43 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2478078 | 0.94 | SYK (0.57) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2473377 | 0.89 | SYK (0.65) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL13288363 | 0.88 | SYK (0.55) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2476048 | 0.81 | SYK (0.68) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2482698 | 0.81 | SYK (0.70) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2477435 | 0.81 | SYK (0.82) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2888957 | 0.81 | SYK (0.63) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL13334146 | 0.81 | SYK (0.57) | SYK | |
| SCHEMBL2475525 | 0.80 | SYK (0.69) | SYKJAK2NTRK1ROS1CSNK2A2 | |
| SCHEMBL2478833 | 0.80 | SYK (0.71) | SYKJAK2NTRK1ROS1CSNK2A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3552607-A2 | IMIDAZOPYRAZINE SYK INHIBITORS | Gilead Connecticut, Inc. (US) | 2019-10-16 | — | — | EP | disclosed |