Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SYK | P43405 | 19/20 | 0.55 |
| ▸ | CD63 | P08962 | 2/20 | 0.51 |
| ▸ | AURKA | O14965 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.51 |
| ▸ | ROS1 | P08922 | 1/20 | 0.51 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.51 |
| ▸ | FLT3 | P36888 | 1/20 | 0.51 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.51 |
| ▸ | BTK | Q06187 | 1/20 | 0.51 |
| ▸ | PTK6 | Q13882 | 1/20 | 0.51 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2477189 | 0.97 | SYK (0.57) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2480231 | 0.89 | SYK (0.67) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2477381 | 0.87 | SYK (0.66) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2471387 | 0.85 | SYK (0.55) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL15551544 | 0.83 | SYK (0.68) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2475878 | 0.79 | SYK (0.65) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2477933 | 0.79 | SYK (0.69) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2474848 | 0.79 | SYK (0.54) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2899022 | 0.79 | SYK (0.59) | SYKCD63AURKAJAK2NTRK1 | |
| SCHEMBL2473693 | 0.78 | SYK (0.60) | SYKCD63AURKAJAK2NTRK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3552607-A2 | IMIDAZOPYRAZINE SYK INHIBITORS | Gilead Connecticut, Inc. (US) | 2019-10-16 | — | — | EP | disclosed |