⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20234248 | 0.81 | KDM4E (0.34) | — | |
| SCHEMBL24789174 | 0.79 | KDM4E (0.36) | — | |
| SCHEMBL22375129 | 0.76 | KDM4E (0.32) | — | |
| SCHEMBL24453193 | 0.73 | KDM4E (0.36) | — | |
| SCHEMBL5541267 | 0.73 | KDM4E (0.39) | — | |
| SCHEMBL26460035 | 0.72 | — | — | |
| SCHEMBL21673610 | 0.72 | KDM4E (0.31) | — | |
| SCHEMBL21472076 | 0.71 | KDM4E (0.33) | — | |
| SCHEMBL20324841 | 0.70 | POLB (0.31) | — | |
| SCHEMBL17552869 | 0.70 | KDM4E (0.39) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11161841-B2 | Modulators of proteolysis and associated methods of use | ARVINAS OPERATIONS, INC. (US) | 2021-11-02 | — | — | US | disclosed |
| US-20190315732-A1 | MODULATORS OF PROTEOLYSIS AND ASSOCIATED METHODS OF USE | ARVINAS OPERATIONS, INC. | 2019-10-17 | — | — | US | disclosed |