Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 16/20 | 0.82 |
| ▸ | MET | P08581 | 1/20 | 0.52 |
| ▸ | KDR | P35968 | 10/20 | 0.52 |
| ▸ | FGFR1 | P11362 | 3/20 | 0.49 |
| ▸ | FLT1 | P17948 | 3/20 | 0.49 |
| ▸ | FLT4 | P35916 | 3/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21473566 | 0.94 | EGFR (0.77) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473567 | 0.92 | EGFR (0.83) | EGFRMETKDRFLT1 | |
| SCHEMBL21473558 | 0.90 | EGFR (1.00) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473608 | 0.90 | EGFR (1.00) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473662 | 0.90 | EGFR (1.00) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21475225 | 0.90 | EGFR (1.00) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473569 | 0.89 | EGFR (0.77) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473665 | 0.89 | EGFR (0.78) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473568 | 0.88 | EGFR (0.77) | EGFRMETKDRFGFR1FLT1 | |
| SCHEMBL21473666 | 0.85 | EGFR (1.00) | EGFRMETKDRFGFR1FLT1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-112236422-B | Quinazoline compound as EGFR three-mutation inhibitor and application thereof | 华东理工大学 | 2023-05-16 | — | — | CN | disclosed |
| US-20210155604-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-05-27 | — | — | US | disclosed |
| EP-3778586-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | East China University of Science and Technology (CN) | 2021-02-17 | — | — | EP | disclosed |
| CN-112236422-A | Quinazoline compound as EGFR (epidermal growth factor receptor) triple mutation inhibitor and application thereof | 华东理工大学 | 2021-01-15 | — | — | CN | disclosed |
| WO-2019196938-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155604-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | EGFR, ERBB2, ERBB4 | EGFR 1/4885MET 25/4885KDR 29/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.