Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.61 |
| ▸ | KDR | P35968 | 10/20 | 0.61 |
| ▸ | FGFR1 | P11362 | 7/20 | 0.61 |
| ▸ | FLT1 | P17948 | 7/20 | 0.61 |
| ▸ | FLT4 | P35916 | 7/20 | 0.61 |
| ▸ | RET | P07949 | 2/20 | 0.61 |
| ▸ | KIF5B | P33176 | 2/20 | 0.61 |
| ▸ | SRC | P12931 | 2/20 | 0.59 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.59 |
| ▸ | TEK | Q02763 | 2/20 | 0.59 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.59 |
| ▸ | PLK4 | O00444 | 1/20 | 0.59 |
| ▸ | CIT | O14578 | 1/20 | 0.59 |
| ▸ | GAK | O14976 | 1/20 | 0.59 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.59 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.59 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.59 |
| ▸ | STK10 | O94804 | 1/20 | 0.59 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.59 |
| ▸ | ABL1 | P00519 | 1/20 | 0.59 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3428791 | 0.88 | EGFR (0.51) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4417734 | 0.86 | EGFR (0.61) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL1613217 | 0.86 | EGFR (0.66) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL30017110 | 0.86 | EGFR (0.66) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL4552440 | 0.84 | EGFR (0.70) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL3425764 | 0.82 | EGFR (0.53) | EGFRKDRRETKIF5BKIT | |
| SCHEMBL4690101 | 0.81 | KDR (0.65) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL30393893 | 0.80 | EGFR (0.64) | EGFRKDRFGFR1FLT1FLT4 | |
| SCHEMBL14095984 | 0.79 | EGFR (0.89) | EGFR | |
| SCHEMBL30891807 | 0.79 | EGFR (0.89) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210155604-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-05-27 | — | — | US | disclosed |
| EP-3778586-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | East China University of Science and Technology (CN) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019196938-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155604-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | EGFR, ERBB2, ERBB4 | EGFR 1/4885KDR 29/4885FGFR1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.