Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.72 |
| ▸ | EGFR | P00533 | 18/20 | 0.71 |
| ▸ | FGFR1 | P11362 | 5/20 | 0.70 |
| ▸ | FLT1 | P17948 | 5/20 | 0.70 |
| ▸ | FLT4 | P35916 | 5/20 | 0.70 |
| ▸ | PDGFRB | P09619 | 2/20 | 0.70 |
| ▸ | TEK | Q02763 | 2/20 | 0.70 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.70 |
| ▸ | PLK4 | O00444 | 1/20 | 0.70 |
| ▸ | CIT | O14578 | 1/20 | 0.70 |
| ▸ | GAK | O14976 | 1/20 | 0.70 |
| ▸ | EPHB6 | O15197 | 1/20 | 0.70 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.70 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.70 |
| ▸ | STK10 | O94804 | 1/20 | 0.70 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.70 |
| ▸ | ABL1 | P00519 | 1/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.70 |
| ▸ | LCK | P06239 | 1/20 | 0.70 |
| ▸ | FYN | P06241 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21473617 | 0.94 | EGFR (0.70) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL30017782 | 0.92 | KDR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL28959245 | 0.91 | KDR (0.70) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL28959225 | 0.91 | EGFR (0.69) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL28959197 | 0.91 | EGFR (0.72) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL28959241 | 0.90 | EGFR (0.77) | KDREGFRROCK2LCKFYN | |
| SCHEMBL28959209 | 0.90 | EGFR (0.67) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL30017257 | 0.90 | KDR (0.69) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL30017747 | 0.90 | EGFR (0.71) | KDREGFRFGFR1FLT1FLT4 | |
| SCHEMBL28959222 | 0.90 | EGFR (0.69) | KDREGFRFGFR1FLT1FLT4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-115403557-A | Quinoline and quinazoline compounds as fourth-generation EGFR (epidermal growth factor receptor) inhibitor and application thereof | 华东理工大学 | 2022-11-29 | — | — | CN | disclosed |
| US-20210155604-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | EAST CHINA UNIVERSITY OF SCIENCE AND TECHNOLOGY (CN) | 2021-05-27 | — | — | US | disclosed |
| EP-3778586-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | East China University of Science and Technology (CN) | 2021-02-17 | — | — | EP | disclosed |
| WO-2019196938-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | 华东理工大学 | 2019-10-17 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210155604-A1 | QUINAZOLINE COMPOUND SERVING AS EGFR TRIPLE MUTATION INHIBITOR AND APPLICATIONS THEREOF | EGFR, ERBB2, ERBB4 | KDR 29/4885EGFR 1/4885FGFR1 10/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.