Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HSP90AB1 | P08238 | 5/20 | 0.58 |
| ▸ | PDE5A | O76074 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.37 |
| ▸ | NPC1 | O15118 | 5/20 | 0.37 |
| ▸ | RAB9A | P51151 | 4/20 | 0.37 |
| ▸ | HPGD | P15428 | 3/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.37 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.36 |
| ▸ | LDHA | P00338 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
| ▸ | PKN1 | Q16512 | 1/20 | 0.35 |
| ▸ | PKN2 | Q16513 | 1/20 | 0.35 |
| ▸ | METAP2 | P50579 | 2/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | GPR55 | Q9Y2T6 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27263584 | 0.87 | HSP90AB1 (0.53) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL12431588 | 0.85 | HSP90AB1 (0.57) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL2315006 | 0.82 | HSP90AB1 (0.50) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL12431147 | 0.82 | HSP90AB1 (0.53) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL13437139 | 0.82 | HSP90AB1 (0.50) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL2312667 | 0.82 | HSP90AB1 (0.50) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL12430602 | 0.82 | HSP90AB1 (0.52) | HSP90AB1PDE5AALDH1A1NPC1RAB9A | |
| SCHEMBL12430427 | 0.81 | HSP90AB1 (0.60) | HSP90AB1PDE5AALDH1A1RAB9AHPGD | |
| SCHEMBL19556862 | 0.81 | HSP90AB1 (0.71) | HSP90AB1PDE5AALDH1A1RAB9AHPGD | |
| SCHEMBL19556863 | 0.80 | HSP90AB1 (0.69) | HSP90AB1PDE5AALDH1A1RAB9AHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019199816-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |