Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH3 | Q9Y5N1 | 9/20 | 0.48 |
| ▸ | SLC6A2 | P23975 | 2/20 | 0.45 |
| ▸ | HRH1 | P35367 | 2/20 | 0.45 |
| ▸ | CHRM2 | P08172 | 1/20 | 0.45 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.45 |
| ▸ | SLC6A4 | P31645 | 1/20 | 0.45 |
| ▸ | SLC6A3 | Q01959 | 1/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.45 |
| ▸ | SCN5A | Q14524 | 1/20 | 0.45 |
| ▸ | CHRM4 | P08173 | 1/20 | 0.44 |
| ▸ | HTR2C | P28335 | 1/20 | 0.44 |
| ▸ | HTR7 | P34969 | 1/20 | 0.44 |
| ▸ | TMEM97 | Q5BJF2 | 1/20 | 0.44 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.42 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20325116 | 0.98 | HRH3 (0.52) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL19991982 | 0.96 | HRH3 (0.48) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL20332762 | 0.94 | HRH3 (0.45) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL20332771 | 0.92 | HRH3 (0.51) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL25009132 | 0.90 | HRH3 (0.58) | HRH3MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL20332383 | 0.90 | HRH3 (0.49) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL10103385 | 0.90 | HRH3 (0.61) | HRH3MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL1277024 | 0.88 | HRH3 (0.54) | HRH3SLC6A2HRH1CHRM2ADRA2C | |
| SCHEMBL501637 | 0.88 | HRH3 (0.52) | HRH3MEN1ALDH1A1CYP1A2CYP2D6 | |
| SCHEMBL21472087 | 0.88 | HRH3 (0.65) | HRH3KCNH2MEN1ALDH1A1CYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019199816-A1 | CEREBLON LIGANDS AND BIFUNCTIONAL COMPOUNDS COMPRISING THE SAME | ARVINAS OPERATIONS, INC. (US) | 2019-10-17 | — | — | WO | disclosed |