Sugi Predict

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SCHEMBL21481944

SCHEMBL21481944

CC(C)c1ccc(Cn2ncc3c(Cl)ccc(C(=O)NC4CC5(C4)CC(C(=O)O)C5)c32)cc1

nearest known ligand 0.44

Predicted protein targets (top 11)

geneUniProtsupporting neighboursconfidence
▸ PTGER4 P35408 2/20 0.44
▸ ROCK2 O75116 7/20 0.35
▸ PKM P14618 2/20 0.34
▸ PKLR P30613 1/20 0.34
▸ NPBWR1 P48145 1/20 0.34
▸ ALDH1A1 P00352 2/20 0.33
▸ HTT P42858 1/20 0.33
▸ SMN1; SMN2 Q16637 1/20 0.33
▸ S1PR1 P21453 1/20 0.33
▸ NR3C1 P04150 2/20 0.33
▸ CNR2 P34972 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21458178 1.00 PTGER4 (0.44) PTGER4ROCK2PKMPKLRNPBWR1
SCHEMBL30843283 0.90 PTGER4 (0.46) PTGER4ROCK2CNR2
SCHEMBL31203152 0.90 CNR2 (0.40) PTGER4PKMPKLRNPBWR1ALDH1A1
SCHEMBL21506721 0.90 PTGER4 (0.46) PTGER4ROCK2SMN1; SMN2CNR2
SCHEMBL31731405 0.90 PTGER4 (0.46) PTGER4ROCK2SMN1; SMN2CNR2
SCHEMBL21506725 0.90 PTGER4 (0.46) PTGER4ROCK2CNR2
SCHEMBL21481897 0.89 PTGER4 (0.49) PTGER4ROCK2S1PR1
SCHEMBL21458196 0.89 PTGER4 (0.49) PTGER4ROCK2S1PR1
SCHEMBL21482134 0.89 PTGER4 (0.49) PTGER4ROCK2ALDH1A1S1PR1CNR2
SCHEMBL21458150 0.89 PTGER4 (0.49) PTGER4ROCK2ALDH1A1S1PR1CNR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-112313208-B Bicyclic carboxamides and methods of use thereof 泰普斯特医疗公司 2024-04-19 — — CN disclosed
US-11795156-B2 Bicyclic carboxamides and methods of use thereof TEMPEST THERAPEUTICS, INC. (US) 2023-10-24 — — US disclosed
US-20230045612-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF TEMPEST THERAPEUTICS, INC. 2023-02-09 — — US disclosed
US-10968201-B2 Bicyclic carboxamides and methods of use thereof TEMPEST THERAPEUTICS, INC. (US) 2021-04-06 — — US disclosed
US-20210024491-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF TEMPEST THERAPEUTICS, INC. 2021-01-28 — — US disclosed
US-20190315712-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF TEMPEST THERAPEUTICS, INC. 2019-10-17 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-11795156-B2 Bicyclic carboxamides and methods of use thereof PTGER4, PTGER2, CNR2 PTGER4 1/4885ROCK2 1715/4885PKM 1746/4885
US-10968201-B2 Bicyclic carboxamides and methods of use thereof PTGER4, PTGER2, CNR2 PTGER4 1/4885ROCK2 1715/4885PKM 1746/4885
US-20230045612-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF PTGER4, PTGER2, CNR2 PTGER4 1/4885ROCK2 1715/4885PKM 1746/4885
US-20210024491-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF PTGER4, PTGER2, CNR2 PTGER4 1/4885ROCK2 1715/4885PKM 1746/4885
US-20190315712-A1 BICYCLIC CARBOXAMIDES AND METHODS OF USE THEREOF PTGER4, PTGER2, CNR2 PTGER4 1/4885ROCK2 1715/4885PKM 1746/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.