Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 12/20 | 0.59 |
| ▸ | PDE3A | Q14432 | 12/20 | 0.59 |
| ▸ | P2RY12 | Q9H244 | 10/20 | 0.59 |
| ▸ | CYSLTR2 | Q9NS75 | 3/20 | 0.51 |
| ▸ | CYSLTR1 | Q9Y271 | 3/20 | 0.51 |
| ▸ | BRD4 | O60885 | 1/20 | 0.46 |
| ▸ | PPARG | P37231 | 2/20 | 0.44 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.43 |
| ▸ | NCF1 | P14598 | 1/20 | 0.43 |
| ▸ | PPARD | Q03181 | 1/20 | 0.43 |
| ▸ | PPARA | Q07869 | 1/20 | 0.43 |
| ▸ | PDE2A | O00408 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL23387027 | 0.90 | PDE3B (0.57) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL23346208 | 0.88 | PDE3B (0.55) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL30876851 | 0.88 | PDE3B (0.55) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL21479647 | 0.87 | PDE3B (0.54) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL21478669 | 0.87 | PDE3B (0.58) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL29211939 | 0.82 | PDE3B (0.60) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL30876852 | 0.82 | PDE3B (0.60) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL21479040 | 0.82 | PDE3B (0.62) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL21479621 | 0.81 | PDE3B (0.61) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 | |
| SCHEMBL30876849 | 0.81 | PDE3B (0.61) | PDE3BPDE3AP2RY12CYSLTR2CYSLTR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019199621-A1 | BI-FUNCTIONAL MOLECULES TO DEGRADE CIRCULATING PROTEINS | YALE UNIVERSITY (US) | 2019-10-17 | — | — | WO | disclosed |