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Sugi Predict / Compounds / SCHEMBL2148305

SCHEMBL2148305

SCHEMBL2148305

C=CCOC1C[C@H](n2cc(C#CCNC(=O)C(F)(F)F)c(N)nc2=O)O[C@@H]1CO

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
▸ DNMT1 P26358 6/20 0.36
▸ POLB P06746 1/20 0.34
▸ DNMT3B Q9UBC3 2/20 0.33
▸ ADRB1 P08588 1/20 0.33
▸ KDM4E B2RXH2 1/20 0.33
▸ ALB P02768 1/20 0.33
▸ RNASE1 P07998 1/20 0.32
▸ FPR2 P25090 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL887493 1.00 DNMT1 (0.36) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL2148299 1.00 DNMT1 (0.36) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL22814998 1.00 DNMT1 (0.36) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL20506690 0.86 DNMT1 (0.35) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL2611638 0.86 DNMT1 (0.38) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL13597631 0.86 DNMT1 (0.35) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL21538141 0.86 DNMT1 (0.35) DNMT1POLBDNMT3BADRB1KDM4E
SCHEMBL22219920 0.85 DNMT1 (0.49) DNMT1DNMT3BADRB1FPR2
SCHEMBL2119433 0.85 DNMT1 (0.49) DNMT1DNMT3BADRB1FPR2
SCHEMBL2119424 0.85 DNMT1 (0.49) DNMT1DNMT3BADRB1FPR2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-11939631-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2024-03-26 — — US disclosed
US-20210381043-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-12-09 — — US disclosed
US-20210381043-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-12-09 — — US disclosed
US-10907194-B2 Synthesis of four-color 3′-O-allyl modified photocleavable fluorescent nucleotides and related methods THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2021-02-02 — — US disclosed
US-20200208211-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-07-02 — — US disclosed
US-20200208211-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2020-07-02 — — US disclosed
US-20190136308-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-05-09 — — US disclosed
US-20190136308-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2019-05-09 — — US disclosed
US-10000801-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2018-06-19 — — US disclosed
US-20170114403-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2017-04-27 — — US disclosed
US-9255292-B2 Synthesis of four-color 3′-O-allyl modified photocleavable fluorescent nucleotides and related methods THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2016-02-09 — — US disclosed
US-20140315191-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-10-23 — — US disclosed
US-20140315191-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2014-10-23 — — US disclosed
US-20130280700-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2013-10-24 — — US disclosed
US-20130280700-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2013-10-24 — — US disclosed
US-8298792-B2 Four-color DNA sequencing by synthesis using cleavable fluorescent nucleotide reversible terminators THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2012-10-30 — — US disclosed
US-20120156680-A1 SYNTHESIS OF FOUR-COLOR 3'-O-ALLYL MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2012-06-21 — — US disclosed
US-20120021408-A1 FOUR-COLOR DNA SEQUENCING BY SYNTHESIS USING CLEAVABLE FLUORESCENT NUCLEOTIDE REVERSIBLE TERMINATORS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK 2012-01-26 — — US disclosed
US-7982029-B2 Synthesis of four color 3′O-allyl, modified photocleavable fluorescent nucleotides and related methods THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2011-07-19 — — US disclosed
US-20100041029-A1 SYNTHESIS OF FOUR COLOR 3'O-ALLYL, MODIFIED PHOTOCLEAVABLE FLUORESCENT NUCLEOTIDES AND RELATED METHODS THE TRUSTEES OF COLUMBIA UNIVERSITY IN THE CITY OF NEW YORK (US) 2010-02-18 — — US disclosed
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