Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 20/20 | 0.56 |
| ▸ | AURKB | Q96GD4 | 20/20 | 0.56 |
| ▸ | AURKC | Q9UQB9 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2148691 | 0.85 | AURKA (0.65) | AURKAAURKBAURKC | |
| SCHEMBL2148608 | 0.85 | AURKA (0.73) | AURKAAURKB | |
| SCHEMBL2148590 | 0.84 | AURKA (0.55) | AURKAAURKBAURKC | |
| SCHEMBL2146393 | 0.83 | AURKA (0.72) | AURKAAURKBAURKC | |
| SCHEMBL2148752 | 0.83 | AURKA (0.59) | AURKAAURKB | |
| SCHEMBL2161525 | 0.83 | AURKA (0.73) | AURKAAURKBAURKC | |
| SCHEMBL2224220 | 0.83 | AURKA (0.69) | AURKAAURKB | |
| SCHEMBL2171510 | 0.83 | AURKA (0.69) | AURKAAURKB | |
| SCHEMBL2152927 | 0.81 | AURKA (0.65) | AURKAAURKB | |
| SCHEMBL2169570 | 0.81 | AURKA (0.64) | AURKAAURKB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |