Sugi Predict

Sugi Predict / Compounds / SCHEMBL21484151

SCHEMBL21484151

SCHEMBL21484151

O=C1CC2(CCN(c3ccc([N+](=O)[O-])cn3)CC2)C(=O)N1

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
▸ CRBN Q96SW2 8/20 1.00
▸ MAPT P10636 5/20 0.59
▸ ALDH1A1 P00352 3/20 0.58
▸ LMNA P02545 1/20 0.58
▸ ALOX12 P18054 1/20 0.58
▸ NPSR1 Q6W5P4 1/20 0.58
▸ CYP1A2 P05177 1/20 0.55
▸ CYP2C9 P11712 1/20 0.55
▸ HPGD P15428 1/20 0.55
▸ MEN1 O00255 4/20 0.53
▸ KMT2A Q03164 4/20 0.53
▸ ATM Q13315 1/20 0.53
▸ DDB1 Q16531 1/20 0.50
▸ L3MBTL1 Q9Y468 2/20 0.47
▸ NPBWR1 P48145 1/20 0.47
▸ MCHR1 Q99705 1/20 0.47
▸ POLB P06746 1/20 0.45
▸ MAPK1 P28482 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21496431 0.85 CRBN (1.00) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL31730129 0.83 CRBN (0.88) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL21484141 0.81 CRBN (1.00) CRBNMAPTALDH1A1LMNAMEN1
SCHEMBL21484130 0.81 CRBN (1.00) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL21508841 0.80 CRBN (0.66) CRBNDDB1
SCHEMBL16969235 0.80 CRBN (0.66) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL29739383 0.78 MAPT (0.70) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL1985036 0.78 MAPT (0.70) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL647899 0.77 MAPT (0.68) CRBNMAPTALDH1A1LMNAALOX12
SCHEMBL21508840 0.77 CRBN (0.62) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 11 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3556760-A1 SPIRO COMPOUNDS F. Hoffmann-La Roche AG (CH) 2019-10-23 — — EP claimed
CN-119751456-A Spiro compounds C4医药公司 2025-04-04 — — CN disclosed
CN-112312904-B Spiro compounds C4医药公司 2025-01-07 — — CN disclosed
US-20230416251-A1 SPIROCYCLIC COMPOUNDS C4 THERAPEUTICS, INC. (US) 2023-12-28 — — US disclosed
US-11584748-B2 Spirocyclic compounds C4 THERAPEUTICS, INC. (US) 2023-02-21 — — US disclosed
US-11584748-B2 Spirocyclic compounds C4 THERAPEUTICS, INC. (US) 2023-02-21 — — US disclosed
EP-3781156-A1 SPIROCYCLIC COMPOUNDS C4 Therapeutics, Inc. (US) 2021-02-24 — — EP disclosed
US-20210032245-A1 SPIROCYCLIC COMPOUNDS C4 THERAPEUTICS, INC. (US) 2021-02-04 — — US disclosed
US-20210032245-A1 SPIROCYCLIC COMPOUNDS C4 THERAPEUTICS, INC. (US) 2021-02-04 — — US disclosed
WO-2019204354-A1 SPIROCYCLIC COMPOUNDS C4 THERAPEUTICS, INC. (US) 2019-10-24 — — WO disclosed
EP-3556760-A1 SPIRO COMPOUNDS F. Hoffmann-La Roche AG (CH) 2019-10-23 — — EP disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20230416251-A1 SPIROCYCLIC COMPOUNDS CRBN, RBX1, XIAP CRBN 1/4885MAPT 3398/4885ALDH1A1 2000/4885
US-20210032245-A1 SPIROCYCLIC COMPOUNDS CRBN, RBX1, XIAP CRBN 1/4885MAPT 3398/4885ALDH1A1 2000/4885
US-11584748-B2 Spirocyclic compounds CRBN, RBX1, XIAP CRBN 1/4885MAPT 3398/4885ALDH1A1 2000/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.