Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.53 |
| ▸ | AXL | P30530 | 1/20 | 0.42 |
| ▸ | MERTK | Q12866 | 1/20 | 0.42 |
| ▸ | BCL2 | P10415 | 1/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21486178 | 0.90 | PIK3CD (0.57) | PIK3CDAXLMERTK | |
| SCHEMBL9929227 | 0.88 | PIK3CD (0.55) | PIK3CDAXLMERTKBCL2PIK3CG | |
| SCHEMBL9929257 | 0.87 | PIK3CD (0.54) | PIK3CDAXLMERTKBCL2 | |
| SCHEMBL9929108 | 0.87 | PIK3CD (0.61) | PIK3CDAXLMERTK | |
| SCHEMBL9929355 | 0.86 | PIK3CD (0.58) | PIK3CDAXLMERTK | |
| SCHEMBL9929153 | 0.86 | PIK3CD (0.55) | PIK3CDAXLMERTKBCL2PIK3CG | |
| SCHEMBL9928985 | 0.86 | PIK3CD (0.61) | PIK3CDAXLMERTK | |
| SCHEMBL9929055 | 0.86 | PIK3CD (0.58) | PIK3CDAXLMERTK | |
| SCHEMBL9929575 | 0.86 | PIK3CD (0.51) | PIK3CDAXLMERTKBCL2PIK3CG | |
| SCHEMBL9929041 | 0.85 | PIK3CD (0.57) | PIK3CDAXLMERTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-B1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE HOLDINGS CORP (US) | 2019-10-23 | — | — | EP | claimed |
| EP-3660016-A1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | Incyte Holdings Corporation (US) | 2020-06-03 | — | — | EP | disclosed |
| EP-2655374-B1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE HOLDINGS CORP (US) | 2019-10-23 | — | — | EP | disclosed |