Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CD | O00329 | 19/20 | 0.41 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.41 |
| ▸ | PIK3R2 | O00459 | 4/20 | 0.41 |
| ▸ | AXL | P30530 | 1/20 | 0.41 |
| ▸ | MERTK | Q12866 | 1/20 | 0.41 |
| ▸ | BCL2 | P10415 | 1/20 | 0.38 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.34 |
| ▸ | PIK3R1 | P27986 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9928864 | 0.80 | PIK3CD (0.41) | PIK3CDPIK3CGPIK3R2AXLMERTK | |
| SCHEMBL9929484 | 0.79 | PIK3CD (0.50) | PIK3CDPIK3CGPIK3R2AXLMERTK | |
| Trifluoroacetic Acid SCHEMBL9928812 | 0.76 | PIK3CD (0.39) | PIK3CDPIK3CGPIK3R2AXLMERTK | |
| Trifluoroacetic Acid SCHEMBL9929324 | 0.75 | PIK3CD (0.47) | PIK3CDPIK3CGAXLMERTKBCL2 | |
| SCHEMBL9929003 | 0.73 | PIK3CD (0.55) | PIK3CDPIK3CGPIK3R2AXLMERTK | |
| SCHEMBL9929305 | 0.73 | PIK3CD (0.43) | PIK3CDPIK3R2AXLMERTKBCL2 | |
| SCHEMBL9929351 | 0.71 | PIK3CD (0.44) | PIK3CDPIK3CGAXLMERTKBCL2 | |
| SCHEMBL9929054 | 0.71 | PIK3CD (0.43) | PIK3CDPIK3R2AXLMERTKBCL2 | |
| SCHEMBL9928901 | 0.70 | PIK3CD (0.53) | PIK3CDPIK3CGPIK3R2AXLMERTK | |
| SCHEMBL10278955 | 0.70 | PIK3CD (0.38) | PIK3CDAXLMERTKBCL2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2655374-B1 | N-(1-(SUBSTITUTED-PHENYL)ETHYL)-9H-PURIN-6-AMINES AS PI3K INHIBITORS | INCYTE HOLDINGS CORP (US) | 2019-10-23 | — | — | EP | disclosed |