Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.49 |
| ▸ | NPC1 | O15118 | 2/20 | 0.49 |
| ▸ | RAB9A | P51151 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.47 |
| ▸ | HTT | P42858 | 1/20 | 0.44 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.44 |
| ▸ | PREP | P48147 | 1/20 | 0.42 |
| ▸ | TMEM97 | Q5BJF2 | 2/20 | 0.42 |
| ▸ | SIGMAR1 | Q99720 | 2/20 | 0.42 |
| ▸ | HTR1A | P08908 | 1/20 | 0.42 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.42 |
| ▸ | HRH2 | P25021 | 1/20 | 0.42 |
| ▸ | HRH1 | P35367 | 1/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 1/20 | 0.42 |
| ▸ | GRIN2B | Q13224 | 4/20 | 0.42 |
| ▸ | JAK2 | O60674 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL17765057 | 0.97 | SMN1; SMN2 (0.47) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL578446 | 0.94 | SMN1; SMN2 (0.54) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL21906706 | 0.93 | MEN1 (0.47) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL3125423 | 0.89 | SMN1; SMN2 (0.52) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL13519203 | 0.82 | SMN1; SMN2 (0.57) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL28563537 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL16333453 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL16340503 | 0.82 | SMN1; SMN2 (0.56) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL21906825 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 | |
| SCHEMBL16340641 | 0.81 | SMN1; SMN2 (0.59) | SMN1; SMN2NPC1RAB9APDE4BCYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |