Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | WHR1 | P49842 | 5/20 | 0.79 |
| ▸ | EHMT1 | Q9H9B1 | 9/20 | 0.71 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.71 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.71 |
| ▸ | EHMT2 | Q96KQ7 | 11/20 | 0.65 |
| ▸ | SPIN1 | Q9Y657 | 2/20 | 0.65 |
| ▸ | NSD2 | O96028 | 1/20 | 0.63 |
| ▸ | KDM1A | O60341 | 1/20 | 0.61 |
| ▸ | RCOR1 | Q9UKL0 | 1/20 | 0.61 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22144601 | 0.90 | WHR1 (0.79) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL21486655 | 0.89 | EHMT2 (0.81) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144596 | 0.89 | WHR1 (0.78) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144597 | 0.89 | WHR1 (1.00) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144594 | 0.88 | WHR1 (0.76) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL30161184 | 0.87 | WHR1 (0.81) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144697 | 0.87 | WHR1 (0.81) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144598 | 0.86 | EHMT2 (0.80) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144628 | 0.86 | SPIN1 (0.76) | WHR1EHMT1HDAC1HDAC6EHMT2 | |
| SCHEMBL22144626 | 0.85 | CCR4 (0.77) | WHR1EHMT1HDAC1HDAC6EHMT2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20190322643-A1 | HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME | GEORGIA STATE UNIVERSITY RESEARCH FOUNDATION, INC. | 2019-10-24 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20190322643-A1 | HISTONE DEACETYLASE AND HISTONE METHYLTRANSFERASE INHIBITORS AND METHODS OF MAKING AND USE OF THE SAME | HDAC1, HDAC2, DOT1L | WHR1 262/4885EHMT1 5/4885HDAC1 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.