Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRNA7 | P36544 | 1/20 | 0.56 |
| ▸ | HSD17B10 | Q99714 | 5/20 | 0.54 |
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | TSHR | P16473 | 1/20 | 0.54 |
| ▸ | CREBBP | Q92793 | 1/20 | 0.54 |
| ▸ | SMYD3 | Q9H7B4 | 6/20 | 0.53 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 1/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | HPGD | P15428 | 2/20 | 0.50 |
| ▸ | GAA | P10253 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
| ▸ | SLC9A1 | P19634 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19701326 | 1.00 | CHRNA7 (0.56) | CHRNA7HSD17B10KDM4ETSHRCREBBP | |
| SCHEMBL2276515 | 0.93 | CHRNA7 (0.61) | CHRNA7HSD17B10KDM4ETSHRCREBBP | |
| SCHEMBL21489788 | 0.85 | SMYD3 (0.53) | CHRNA7HSD17B10KDM4ETSHRCREBBP | |
| SCHEMBL19701325 | 0.85 | SMYD3 (0.53) | CHRNA7HSD17B10KDM4ETSHRCREBBP | |
| SCHEMBL3598403 | 0.80 | CHRNA7 (0.54) | CHRNA7HSD17B10KDM4ETSHRCREBBP | |
| SCHEMBL3598401 | 0.80 | CHRNA7 (0.54) | CHRNA7HSD17B10KDM4ETSHRCREBBP | |
| SCHEMBL30525414 | 0.76 | MCL1 (0.65) | CHRNA7MCL1GAAMEN1NPC1 | |
| SCHEMBL8252421 | 0.76 | CHRNA7 (0.52) | CHRNA7HSD17B10KDM4EMCL1CNR2 | |
| SCHEMBL4153134 | 0.76 | CHRNA7 (0.52) | CHRNA7HSD17B10KDM4EMCL1CNR2 | |
| SCHEMBL8248425 | 0.75 | CHRNA7 (0.54) | CHRNA7HSD17B10KDM4EMCL1CNR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | EPIZYME INC (US) | 2021-07-01 | — | — | US | claimed |
| US-20190322660-A1 | SMYD INHIBITORS | Epizyme, Inc. | 2019-10-24 | — | — | US | claimed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210198252-A1 | SMYD INHIBITORS | SMYD3, SMYD2, SMURF2 | CHRNA7 4717/4885HSD17B10 2515/4885KDM4E 139/4885 |
| US-20190322660-A1 | SMYD INHIBITORS | SMYD2, SMYD3, SMURF2 | CHRNA7 4700/4885HSD17B10 2639/4885KDM4E 233/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.