Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Donepezil. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 8/20 | 1.00 |
| ▸ | BCHE | P06276 | 8/20 | 1.00 |
| ▸ | FAAH | O00519 | 1/20 | 1.00 |
| ▸ | ABCC4 | O15439 | 1/20 | 1.00 |
| ▸ | CACNA1F | O60840 | 1/20 | 1.00 |
| ▸ | PDE5A | O76074 | 1/20 | 1.00 |
| ▸ | ABCB11 | O95342 | 1/20 | 1.00 |
| ▸ | APP | P05067 | 1/20 | 1.00 |
| ▸ | CHRM2 | P08172 | 1/20 | 1.00 |
| ▸ | ABCB1 | P08183 | 1/20 | 1.00 |
| ▸ | CYP3A4 | P08684 | 1/20 | 1.00 |
| ▸ | CHRM5 | P08912 | 1/20 | 1.00 |
| ▸ | ADRA2A | P08913 | 1/20 | 1.00 |
| ▸ | CHRM1 | P11229 | 1/20 | 1.00 |
| ▸ | ADRA2C | P18825 | 1/20 | 1.00 |
| ▸ | DRD4 | P21917 | 1/20 | 1.00 |
| ▸ | SLC6A2 | P23975 | 1/20 | 1.00 |
| ▸ | MAOB | P27338 | 1/20 | 1.00 |
| ▸ | AGTR1 | P30556 | 1/20 | 1.00 |
| ▸ | ADRA1A | P35348 | 1/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Donepezil SCHEMBL3851203 | 1.00 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL3516 | 1.00 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL8265876 | 1.00 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL12043710 | 1.00 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL4979379 | 0.99 | BCHE (0.98) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL356844 | 0.99 | BCHE (0.98) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL1559622 | 0.99 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL1815 | 0.99 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL17352708 | 0.99 | BCHE (0.98) | BCHEACHEFAAHABCC4CACNA1F | |
| Donepezil SCHEMBL5060933 | 0.99 | BCHE (1.00) | BCHEACHEFAAHABCC4CACNA1F |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Appears in 49184 patents — a generic fragment claimed broadly, so it's down-weighted as IP noise. Top by claim status then date:
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20260144762-A1 | TRANSDERMAL DELIVERY SYSTEM WITH A MICROPOROUS MEMBRANE HAVING SOLVENT-FILLED PORES | CORIUM, LLC (US) | 2026-05-28 | — | — | US | claimed |
| EP-3733168-B1 | TRANSDERMAL ABSORPTION AGENT COMPRISING DONEPEZIL FOR TREATMENT OF DEMENTIA | DONG A ST CO LTD (KR) | 2026-05-27 | — | — | EP | claimed |
| CN-122094963-A | Cardioprotective lipids and methods of use | — | 2026-05-26 | — | — | CN | claimed |
| CN-122059904-A | Synthetic multi-substituted method for preparing North Rate | 重庆圣华曦药业股份有限公司 | 2026-05-19 | — | — | CN | claimed |
| WO-2026100654-A1 | NUCLEIC ACID INTRODUCTION AID, NUCLEIC ACID INTRODUCTION AGENT, AND NUCLEIC ACID INTRODUCTION METHOD | 株式会社インファーマシア | 2026-05-15 | — | — | WO | claimed |
| WO-2026102000-A1 | COMPOSITIONS AND METHODS FOR THE TREATMENT OF DISORDERS RELATED TO GLUCOSYLCERAMIDASE BETA 1 DEFICIENCY | VOYAGER THERAPEUTICS, INC. (US) | 2026-05-15 | — | — | WO | claimed |
| CN-122031495-A | Application of isofraxidin in treating neurodegenerative diseases | 中日友好医院(中日友好临床医学研究所) | 2026-05-15 | — | — | CN | claimed |
| EP-4429648-B1 | NOVEL SYNERGISTIC COMBINATIONS BASED ON FLUOROETHYLNOREMMANTINE (FENM) AND AN ACETYLCHOLINESTERASE INHIBITOR FOR USE IN THE TREATMENT OF NEURODEGEATIVE DISEASES | REST THERAPEUTICS (FR) | 2026-05-13 | — | — | EP | claimed |
| CN-122010730-A | Preparation method of key intermediate of Lutrepah | 重庆常捷医药有限公司 | 2026-05-12 | — | — | CN | claimed |
| US-12616686-B2 | Donepezil oral films | XIAMEN LP PHARMACEUTICAL CO., LTD. (CN) | 2026-05-05 | — | — | US | claimed |
| WO-1999008672-A1 | USE OF CHOLINESTERASE INHIBITOR FOR TREATING DISEASES ASSOCIATED WITH PROTEOLYTIC ENZYME ACTIVITY | SHIRE INTERNATIONAL LICENSING BV (NL) | 1999-02-25 | — | — | WO | claimed |
| WO-1999007359-A1 | USE OF CHOLINESTERASE INHIBITORS FOR TREATING ATTENTION DEFICIT DISORDERS | SHIRE INTERNATIONAL LICENSING B.V. (NL) | 1999-02-18 | — | — | WO | claimed |
| WO-1998039000-A1 | USE OF CHOLINESTERASE INHIBITORS TO TREAT DISORDERS OF ATTENTION | EISAI CO., LTD. (JP) | 1998-09-11 | — | — | WO | claimed |
| WO-1998030243-A1 | ACETYLCHOLINESTERASE INHIBITORS IN COMBINATION WITH MUSCARINIC AGONISTS FOR THE TREATMENT OF ALZHEIMER'S DISEASE | WARNER-LAMBERT COMPANY (US) | 1998-07-16 | — | — | WO | claimed |
| WO-1997046527-A1 | POLYMORPHS OF DONEPEZIL HYDROCHLORIDE AND PROCESS FOR PRODUCTION | EISAI CO., LTD. (JP) | 1997-12-11 | — | — | WO | claimed |
| WO-1997046526-A1 | STABLE POLYMORPHS OF DONEPEZIL (1-BENZYL-4-[(5,6-DIMETHOXY-1-INDANON)-2-YL]METHYLPIPERIDINE) HYDROCHLORIDE AND PROCESS FOR PRODUCTION | EISAI CO., LTD. (JP) | 1997-12-11 | — | — | WO | claimed |
| EP-0296560-B1 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | EISAI CO LTD (JP) | 1996-02-28 | — | — | EP | claimed |
| EP-0673927-A1 | 4-[2-indanyl-1-one]alkylpiperidines as anticholinergic agents | Eisai Co., Ltd. (JP) | 1995-09-27 | — | — | EP | claimed |
| US-4895841-A | Cyclic amine compounds with activity against acetylcholinesterase | EISAI CO., LTD. (JP) | 1990-01-23 | — | — | US | claimed |
| EP-0296560-A2 | 1,4-Substituted piperidines as acetylcholinesterase inhibitors and their use for the treatment of Alzheimer's disease | Eisai Co., Ltd. (JP) | 1988-12-28 | — | — | EP | claimed |