SCHEMBL21494375

SCHEMBL21494375

O=C(O)CC(=O)Oc1c([N+](=O)[O-])cnc2ccc(Br)cc12

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HTT P42858 3/20 0.40
TSHR P16473 1/20 0.40
MAPT P10636 4/20 0.38
MAPK1 P28482 3/20 0.38
ALDH1A1 P00352 2/20 0.38
MEN1 O00255 1/20 0.38
TNF P01375 1/20 0.38
POLB P06746 1/20 0.38
CRHBP P24387 1/20 0.38
KMT2A Q03164 1/20 0.38
CRHR2 Q13324 1/20 0.38
CTDSP1 Q9GZU7 1/20 0.38
NOD2 Q9HC29 1/20 0.38
TDP1 Q9NUW8 1/20 0.38
NOD1 Q9Y239 1/20 0.38
RXFP1 Q9HBX9 2/20 0.38
GAA P10253 2/20 0.36
NPSR1 Q6W5P4 1/20 0.36
PTGFR P43088 1/20 0.36
PKM P14618 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21494374 0.94 HTT (0.45) HTTTSHRMAPTMAPK1ALDH1A1
SCHEMBL21494448 0.83 HTT (0.46) HTTTSHRMAPTMAPK1ALDH1A1
SCHEMBL21494401 0.80 HTT (0.39) HTTTSHRMAPTMAPK1ALDH1A1
SCHEMBL21494361 0.79 HTT (0.38) HTTTSHRMAPTMAPK1ALDH1A1
SCHEMBL26129153 0.77 HTT (0.46) HTTTSHRMAPTMAPK1ALDH1A1
SCHEMBL7674667 0.75 MEN1 (0.42) TSHRMAPTMAPK1ALDH1A1MEN1
SCHEMBL7674671 0.75 MEN1 (0.42) TSHRMAPTMAPK1ALDH1A1MEN1
SCHEMBL27125305 0.75 MAPK1 (0.42) MAPTMAPK1ALDH1A1MEN1POLB
SCHEMBL358629 0.74 MAPT (0.45) HTTTSHRMAPTMAPK1ALDH1A1
SCHEMBL3470550 0.74 MAPT (0.34) HTTMAPTMAPK1ALDH1A1MEN1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3784671-A1 DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY XRad Therapeutics, Inc. (US) 2021-03-03 EP disclosed
WO-2019201283-A1 DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY XRAD THERAPEUTICS, INC. (US) 2019-10-24 WO disclosed