Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 14/20 | 0.64 |
| ▸ | NPC1 | O15118 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | BACE1 | P56817 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055628 | 1.00 | IDO1 (0.64) | IDO1NPC1ALDH1A1GAARAB9A | |
| SCHEMBL24118631 | 1.00 | IDO1 (0.64) | IDO1NPC1ALDH1A1GAARAB9A | |
| SCHEMBL29639839 | 0.85 | IDO1 (0.56) | IDO1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL23572590 | 0.85 | IDO1 (0.56) | IDO1NPC1RAB9ASMN1; SMN2 | |
| SCHEMBL30057681 | 0.84 | IDO1 (0.72) | IDO1NPC1ALDH1A1GAARAB9A | |
| SCHEMBL24118289 | 0.84 | IDO1 (0.72) | IDO1NPC1ALDH1A1GAARAB9A | |
| SCHEMBL24118309 | 0.82 | IDO1 (0.74) | IDO1NPC1ALDH1A1GAARAB9A | |
| SCHEMBL30055468 | 0.82 | IDO1 (0.74) | IDO1NPC1ALDH1A1GAARAB9A | |
| SCHEMBL21504265 | 0.82 | IDO1 (0.64) | IDO1 | |
| SCHEMBL21496357 | 0.80 | IDO1 (0.66) | IDO1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |