Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 14/20 | 0.67 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | RAB9A | P51151 | 1/20 | 0.41 |
| ▸ | CSF1R | P07333 | 1/20 | 0.40 |
| ▸ | RET | P07949 | 1/20 | 0.40 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.40 |
| ▸ | KIT | P10721 | 1/20 | 0.40 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.40 |
| ▸ | FLT3 | P36888 | 1/20 | 0.40 |
| ▸ | HTR1A | P08908 | 1/20 | 0.40 |
| ▸ | HTR2A | P28223 | 1/20 | 0.40 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | DRD3 | P35462 | 1/20 | 0.40 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21504298 | 1.00 | IDO1 (0.67) | IDO1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL24118309 | 0.84 | IDO1 (0.74) | IDO1SMN1; SMN2MAPTNPC1ALDH1A1 | |
| SCHEMBL30055468 | 0.84 | IDO1 (0.74) | IDO1SMN1; SMN2MAPTNPC1ALDH1A1 | |
| SCHEMBL21496351 | 0.83 | IDO1 (0.76) | IDO1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL21496353 | 0.83 | IDO1 (0.76) | IDO1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL24118368 | 0.82 | IDO1 (0.63) | IDO1SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL30055209 | 0.82 | IDO1 (0.63) | IDO1SMN1; SMN2NPC1ALDH1A1GAA | |
| SCHEMBL24118289 | 0.82 | IDO1 (0.72) | IDO1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL30057681 | 0.82 | IDO1 (0.72) | IDO1SMN1; SMN2LMNAMAPTNPC1 | |
| SCHEMBL21496414 | 0.81 | IDO1 (0.69) | IDO1NPC1RAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |