Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 15/20 | 0.68 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.45 |
| ▸ | TRPM8 | Q7Z2W7 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496467 | 1.00 | IDO1 (0.68) | IDO1EGLN1TRPM8MEN1KMT2A | |
| SCHEMBL24118615 | 1.00 | IDO1 (0.68) | IDO1EGLN1TRPM8MEN1KMT2A | |
| SCHEMBL21496353 | 0.86 | IDO1 (0.76) | IDO1 | |
| SCHEMBL21496351 | 0.86 | IDO1 (0.76) | IDO1 | |
| SCHEMBL24118285 | 0.83 | IDO1 (0.50) | IDO1TRPM8 | |
| SCHEMBL24117963 | 0.81 | IDO1 (1.00) | IDO1 | |
| SCHEMBL24118078 | 0.81 | IDO1 (1.00) | IDO1 | |
| SCHEMBL21496393 | 0.81 | IDO1 (0.63) | IDO1 | |
| SCHEMBL21496346 | 0.81 | IDO1 (0.68) | IDO1MEN1KMT2A | |
| SCHEMBL30057665 | 0.81 | IDO1 (0.68) | IDO1MEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |