Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 12/20 | 0.83 |
| ▸ | SLC2A1 | P11166 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 2/20 | 0.47 |
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.47 |
| ▸ | PKM | P14618 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | CASP3 | P42574 | 1/20 | 0.42 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30055991 | 1.00 | IDO1 (0.83) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL21496469 | 1.00 | IDO1 (0.83) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL30055271 | 0.94 | IDO1 (0.76) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL21496512 | 0.94 | IDO1 (0.76) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL21496511 | 0.94 | IDO1 (0.76) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL21496521 | 0.94 | IDO1 (0.76) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL30055491 | 0.94 | IDO1 (0.76) | IDO1SLC2A1NPC1RAB9AKDM4E | |
| SCHEMBL24118299 | 0.91 | IDO1 (1.00) | IDO1SMN1; SMN2 | |
| SCHEMBL21496273 | 0.91 | IDO1 (1.00) | IDO1SMN1; SMN2 | |
| SCHEMBL21496274 | 0.91 | IDO1 (1.00) | IDO1SMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |