SCHEMBL21496479

SCHEMBL21496479

O=C1CC[C@@]2(CCN(C(=O)c3cccc4c3CCN4C(=O)O)C2)C(=O)N1

nearest known ligand 0.67

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
CRBN Q96SW2 20/20 0.67
DDB1 Q16531 1/20 0.50

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL21496427 0.91 CRBN (0.66) CRBNDDB1
SCHEMBL30242817 0.91 CRBN (0.66) CRBNDDB1
SCHEMBL26970063 0.86 CRBN (0.60) CRBNDDB1
SCHEMBL21496410 0.81 CRBN (1.00) CRBNDDB1
SCHEMBL30242818 0.81 CRBN (1.00) CRBNDDB1
SCHEMBL21496450 0.79 CRBN (1.00) CRBNDDB1
SCHEMBL30242874 0.79 CRBN (1.00) CRBNDDB1
SCHEMBL21496439 0.78 CRBN (0.78) CRBNDDB1
SCHEMBL30242833 0.73 CRBN (1.00) CRBNDDB1
SCHEMBL22932158 0.73 CRBN (1.00) CRBNDDB1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-3781156-A1 SPIROCYCLIC COMPOUNDS C4 Therapeutics, Inc. (US) 2021-02-24 EP disclosed
WO-2019204354-A1 SPIROCYCLIC COMPOUNDS C4 THERAPEUTICS, INC. (US) 2019-10-24 WO disclosed