Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 12/20 | 0.69 |
| ▸ | DDB1 | Q16531 | 3/20 | 0.60 |
| ▸ | CTSB | P07858 | 1/20 | 0.42 |
| ▸ | CTSK | P43235 | 1/20 | 0.42 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.41 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.41 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.41 |
| ▸ | OGFRL1 | Q5TC84 | 1/20 | 0.41 |
| ▸ | SCN9A | Q15858 | 4/20 | 0.40 |
| ▸ | LTA4H | P09960 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30242926 | 0.82 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL21484150 | 0.82 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL30242825 | 0.81 | CRBN (1.00) | CRBNDDB1CTSBCTSKSCN9A | |
| SCHEMBL21484140 | 0.81 | CRBN (1.00) | CRBNDDB1CTSBCTSKSCN9A | |
| SCHEMBL23067574 | 0.75 | CRBN (1.00) | CRBNDDB1 | |
| SCHEMBL30465065 | 0.75 | CRBN (1.00) | CRBNDDB1SCN9A | |
| SCHEMBL23067569 | 0.75 | CRBN (1.00) | CRBNDDB1SCN9A | |
| SCHEMBL8123488 | 0.74 | HTR2C (0.47) | CTSBCTSKSCN9A | |
| SCHEMBL4142481 | 0.74 | CRBN (0.57) | CRBNDDB1SCN9A | |
| SCHEMBL22932061 | 0.72 | CRBN (0.58) | CRBNDDB1SCN9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781156-A1 | SPIROCYCLIC COMPOUNDS | C4 Therapeutics, Inc. (US) | 2021-02-24 | — | — | EP | disclosed |
| WO-2019204354-A1 | SPIROCYCLIC COMPOUNDS | C4 THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |