Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 16/20 | 0.70 |
| ▸ | S1PR3 | Q99500 | 3/20 | 0.40 |
| ▸ | S1PR1 | P21453 | 2/20 | 0.39 |
| ▸ | NAMPT | P43490 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496542 | 1.00 | IDO1 (0.70) | IDO1S1PR3S1PR1NAMPT | |
| SCHEMBL21496525 | 0.90 | IDO1 (0.77) | IDO1S1PR3 | |
| SCHEMBL30055476 | 0.90 | IDO1 (0.77) | IDO1S1PR3 | |
| SCHEMBL21496528 | 0.90 | IDO1 (0.77) | IDO1S1PR3 | |
| SCHEMBL21504027 | 0.87 | IDO1 (0.84) | IDO1 | |
| SCHEMBL30056908 | 0.87 | IDO1 (0.84) | IDO1 | |
| SCHEMBL21504016 | 0.87 | IDO1 (0.84) | IDO1 | |
| SCHEMBL30055192 | 0.87 | IDO1 (0.84) | IDO1 | |
| SCHEMBL24118260 | 0.85 | IDO1 (0.80) | IDO1S1PR3 | |
| SCHEMBL24117940 | 0.85 | IDO1 (0.80) | IDO1S1PR3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3781142-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | Merck Sharp&Dohme Corp. (US) | 2021-02-24 | — | — | EP | claimed |
| WO-2019204180-A1 | NOVEL [1.1.1] BICYCLO COMPOUNDS AS INDOLEAMINE 2,3-DIOXYGENASE INHIBITORS | MERCK SHARP & DOHME CORP. (US) | 2019-10-24 | — | — | WO | claimed |