Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC11 | Q96DB2 | 8/20 | 0.81 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.43 |
| ▸ | AR | P10275 | 3/20 | 0.38 |
| ▸ | JAK2 | O60674 | 4/20 | 0.37 |
| ▸ | JAK1 | P23458 | 4/20 | 0.37 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.36 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.36 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.36 |
| ▸ | PTGES | O14684 | 1/20 | 0.36 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21496663 | 0.90 | HDAC11 (0.80) | HDAC11HDAC8TRPV1ARUSP30 | |
| SCHEMBL21496846 | 0.90 | HDAC11 (1.00) | HDAC11HDAC8TRPV1ARUSP30 | |
| SCHEMBL21496665 | 0.85 | HDAC11 (0.59) | HDAC11HDAC8TRPV1EPHX2 | |
| SCHEMBL21496660 | 0.76 | HDAC11 (0.79) | HDAC11HDAC8 | |
| SCHEMBL30039900 | 0.76 | HDAC11 (0.75) | HDAC11HDAC8 | |
| SCHEMBL21500576 | 0.76 | HDAC11 (0.75) | HDAC11HDAC8 | |
| SCHEMBL25932218 | 0.75 | HDAC11 (0.59) | HDAC11HDAC8 | |
| SCHEMBL25932217 | 0.75 | HDAC11 (0.76) | HDAC11HDAC8 | |
| SCHEMBL21496849 | 0.74 | HDAC11 (0.74) | HDAC11HDAC8 | |
| SCHEMBL21496709 | 0.74 | HDAC11 (0.58) | HDAC11HDAC8TRPV1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3784654-A1 | ISOINDOLINES AS HDAC INHIBITORS | Valo Early Discovery, Inc. (US) | 2021-03-03 | — | — | EP | disclosed |
| WO-2019204550-A1 | ISOINDOLINES AS HDAC INHIBITORS | FORMA THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |