Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | ATM | Q13315 | 1/20 | 0.37 |
| ▸ | KDM4A | O75164 | 1/20 | 0.37 |
| ▸ | CACNA1H | O95180 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.36 |
| ▸ | EZH2 | Q15910 | 5/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.35 |
| ▸ | IDO1 | P14902 | 2/20 | 0.35 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.35 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | PARP1 | P09874 | 1/20 | 0.34 |
| ▸ | EPAS1 | Q99814 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21500329 | 0.86 | EZH2 (0.46) | EZH2 | |
| SCHEMBL21489632 | 0.82 | EZH2 (0.39) | EZH2 | |
| SCHEMBL16120372 | 0.73 | EZH2 (0.51) | EZH2 | |
| SCHEMBL21500320 | 0.72 | GAA (0.45) | POLBMAPK1ATMKDM4ACACNA1H | |
| SCHEMBL16377050 | 0.71 | EZH2 (0.43) | KDM4ACACNA1HCACNA1BCACNA1CEZH2 | |
| SCHEMBL25930340 | 0.70 | EZH2 (0.48) | EZH2 | |
| SCHEMBL17885417 | 0.70 | EZH2 (0.46) | KDM4ACACNA1HCACNA1BCACNA1CEZH2 | |
| SCHEMBL21489628 | 0.70 | KDM4E (0.33) | KDM4E | |
| SCHEMBL30785587 | 0.69 | CACNA1H (0.49) | POLBKDM4ACACNA1HCACNA1BCACNA1C | |
| SCHEMBL29872375 | 0.69 | MAPKAPK2 (0.41) | POLBMAPK1ATMKDM4ACACNA1H |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-12612390-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2026-04-28 | — | — | US | disclosed |
| EP-4421072-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | Constellation Pharmaceuticals, Inc. (US) | 2024-08-28 | — | — | EP | disclosed |
| US-20240116905-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2024-04-11 | — | — | US | disclosed |
| EP-3781561-B1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS INC (US) | 2024-03-13 | — | — | EP | disclosed |
| US-11274095-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2022-03-15 | — | — | US | disclosed |
| US-20200317651-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2020-10-08 | — | — | US | disclosed |
| US-10689371-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2020-06-23 | — | — | US | disclosed |
| US-20190322651-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. | 2019-10-24 | — | — | US | disclosed |
| WO-2019204490-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | CONSTELLATION PHARMACEUTICALS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20240116905-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | TPMT, TET1, DNMT1 | POLB 508/4885MAPK1 3060/4885ATM 2784/4885 |
| US-20190322651-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | TPMT, TET1, DNMT1 | POLB 508/4885MAPK1 3060/4885ATM 2784/4885 |
| US-20200317651-A1 | MODULATORS OF METHYL MODIFYING ENZYMES, COMPOSITIONS AND USES THEREOF | TPMT, TET1, DNMT1 | POLB 508/4885MAPK1 3060/4885ATM 2784/4885 |
| US-10689371-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | TPMT, TET1, DNMT1 | POLB 508/4885MAPK1 3060/4885ATM 2784/4885 |
| US-11274095-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | TPMT, TET1, DNMT1 | POLB 508/4885MAPK1 3060/4885ATM 2784/4885 |
| US-12612390-B2 | Modulators of methyl modifying enzymes, compositions and uses thereof | NSD1, DOT1L, EHMT2 | POLB 157/4885MAPK1 3920/4885ATM 1846/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.