Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHEK1 | O14757 | 17/20 | 0.41 |
| ▸ | CCNA2 | P20248 | 16/20 | 0.41 |
| ▸ | CDK2 | P24941 | 16/20 | 0.41 |
| ▸ | CCNA1 | P78396 | 16/20 | 0.41 |
| ▸ | GRM2 | Q14416 | 1/20 | 0.38 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | PIM1 | P11309 | 2/20 | 0.37 |
| ▸ | MAP2K2 | P36507 | 2/20 | 0.37 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.37 |
| ▸ | MET | P08581 | 1/20 | 0.37 |
| ▸ | FGFR1 | P11362 | 1/20 | 0.37 |
| ▸ | FLT3 | P36888 | 1/20 | 0.37 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.37 |
| ▸ | GSK3B | P49841 | 1/20 | 0.37 |
| ▸ | NTRK3 | Q16288 | 1/20 | 0.37 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.37 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.37 |
| ▸ | RPS6KA4 | O75676 | 1/20 | 0.36 |
| ▸ | STK10 | O94804 | 1/20 | 0.36 |
| ▸ | LATS1 | O95835 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26939 | 0.85 | CHEK1 (0.41) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| Bicarbonate SCHEMBL17836378 | 0.84 | CHEK1 (0.37) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL15007376 | 0.82 | CHEK1 (0.35) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL15031503 | 0.82 | CHEK1 (0.35) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL15007377 | 0.82 | CHEK1 (0.35) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL31398 | 0.82 | CHEK1 (0.33) | CHEK1CCNA2CDK2CCNA1TYK2 | |
| SCHEMBL28745 | 0.81 | CHEK1 (0.36) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL28827 | 0.81 | CHEK1 (0.36) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL20975 | 0.81 | CHEK1 (0.36) | CHEK1CCNA2CDK2CCNA1GRM2 | |
| SCHEMBL10236906 | 0.80 | CHEK1 (0.42) | CHEK1CCNA2CDK2CCNA1GRM2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2012027236-A1 | NOVEL PYRAZOLO[1,5-a]PYRIMIDINE DERIVATIVES AS mTOR INHIBITORS | SCHERING CORPORATION (US) | 2012-03-01 | — | — | WO | disclosed |