Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ATM | Q13315 | 7/20 | 0.48 |
| ▸ | PRKDC | P78527 | 4/20 | 0.48 |
| ▸ | CDC7 | O00311 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.35 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.35 |
| ▸ | PIM1 | P11309 | 1/20 | 0.35 |
| ▸ | PRKACA | P17612 | 1/20 | 0.35 |
| ▸ | CDK2 | P24941 | 1/20 | 0.35 |
| ▸ | GSK3B | P49841 | 1/20 | 0.35 |
| ▸ | HIPK2 | Q9H2X6 | 1/20 | 0.35 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.35 |
| ▸ | MTOR | P42345 | 5/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 6/20 | 0.34 |
| ▸ | ATR | Q13535 | 4/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.31 |
| ▸ | TLR9 | Q9NR96 | 1/20 | 0.31 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.31 |
| ▸ | GRK2 | P25098 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL26133023 | 0.88 | PRKDC (0.57) | ATMPRKDCMTORPIK3CDPIK3CA | |
| Hydrochloric Acid SCHEMBL29969815 | 0.88 | PRKDC (0.57) | ATMPRKDCMTORPIK3CDPIK3CA | |
| SCHEMBL29969176 | 0.87 | ATM (0.45) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL29968770 | 0.78 | PRKDC (0.69) | ATMPRKDCMTORPIK3CDPIK3CA | |
| SCHEMBL21512956 | 0.78 | PRKDC (0.69) | ATMPRKDCMTORPIK3CDPIK3CA | |
| SCHEMBL29968617 | 0.77 | ATM (0.53) | ATMPRKDCMTORPIK3CAATR | |
| SCHEMBL21512943 | 0.76 | PRKDC (0.70) | ATMPRKDCMTORPIK3CDPIK3CA | |
| SCHEMBL30613758 | 0.76 | PRKDC (0.70) | ATMPRKDCMTORPIK3CDPIK3CA | |
| SCHEMBL21512618 | 0.75 | PRKDC (0.64) | ATMPRKDCMTORPIK3CDPIK3CA | |
| SCHEMBL29970246 | 0.75 | PRKDC (0.64) | ATMPRKDCMTORPIK3CDPIK3CA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |