Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PRKDC | P78527 | 2/20 | 0.38 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 7/20 | 0.34 |
| ▸ | OPRL1 | P41146 | 2/20 | 0.32 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.32 |
| ▸ | ATM | Q13315 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29969283 | 1.00 | PRKDC (0.38) | PRKDCIRAK4CHRM1OPRL1OPRM1 | |
| SCHEMBL29969709 | 0.99 | PRKDC (0.39) | PRKDCIRAK4CHRM1OPRL1OPRM1 | |
| SCHEMBL21513687 | 0.99 | PRKDC (0.39) | PRKDCIRAK4CHRM1OPRL1OPRM1 | |
| SCHEMBL21513681 | 0.97 | PRKDC (0.39) | PRKDCIRAK4CHRM1ATM | |
| SCHEMBL29969799 | 0.97 | PRKDC (0.39) | PRKDCIRAK4CHRM1ATM | |
| SCHEMBL21513694 | 0.95 | IRAK4 (0.39) | PRKDCIRAK4CHRM1OPRL1OPRM1 | |
| SCHEMBL29969934 | 0.91 | IRAK4 (0.37) | PRKDCIRAK4CHRM1OPRL1OPRM1 | |
| SCHEMBL26129474 | 0.91 | IRAK4 (0.37) | PRKDCIRAK4CHRM1OPRL1OPRM1 | |
| SCHEMBL29968693 | 0.90 | IRAK4 (0.36) | PRKDCIRAK4 | |
| SCHEMBL29968853 | 0.90 | IRAK4 (0.42) | PRKDCIRAK4CHRM1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-4327877-A2 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRad Therapeutics, Inc. (US) | 2024-02-28 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| EP-3784671-B1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS INC (US) | 2023-10-11 | — | — | EP | disclosed |
| WO-2019201283-A1 | DUAL ATM AND DNA-PK INHIBITORS FOR USE IN ANTI-TUMOR THERAPY | XRAD THERAPEUTICS, INC. (US) | 2019-10-24 | — | — | WO | disclosed |