Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CHRM4 | P08173 | 14/20 | 0.66 |
| ▸ | CDC7 | O00311 | 1/20 | 0.63 |
| ▸ | PLK4 | O00444 | 1/20 | 0.63 |
| ▸ | IKBKB | O14920 | 1/20 | 0.63 |
| ▸ | AURKA | O14965 | 1/20 | 0.63 |
| ▸ | CHUK | O15111 | 1/20 | 0.63 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.63 |
| ▸ | FYN | P06241 | 1/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.63 |
| ▸ | PRKACA | P17612 | 1/20 | 0.63 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.63 |
| ▸ | CDK2 | P24941 | 1/20 | 0.63 |
| ▸ | MARK3 | P27448 | 1/20 | 0.63 |
| ▸ | AKT1 | P31749 | 1/20 | 0.63 |
| ▸ | FLT4 | P35916 | 1/20 | 0.63 |
| ▸ | KDR | P35968 | 1/20 | 0.63 |
| ▸ | CSNK1D | P48730 | 1/20 | 0.63 |
| ▸ | GSK3A | P49840 | 1/20 | 0.63 |
| ▸ | LIMK1 | P53667 | 1/20 | 0.63 |
| ▸ | PRKCD | Q05655 | 1/20 | 0.63 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30137733 | 1.00 | CHRM4 (0.66) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL21523008 | 0.80 | CHRM4 (1.00) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL4903009 | 0.77 | CDC7 (1.00) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL21523000 | 0.75 | CHRM4 (0.69) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL21523001 | 0.73 | CHRM4 (1.00) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL19741120 | 0.72 | CHRM4 (1.00) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL19741084 | 0.72 | CHRM4 (1.00) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL30187781 | 0.72 | CHRM4 (1.00) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL21522994 | 0.71 | CHRM4 (0.97) | CHRM4CDC7PLK4IKBKBAURKA | |
| SCHEMBL21522999 | 0.70 | CHRM4 (1.00) | CHRM4CDC7PLK4IKBKBAURKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3558309-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | UNIV VANDERBILT (US) | 2023-07-26 | — | — | EP | claimed |
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-03-30 | — | — | US | claimed |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-10-31 | — | — | US | claimed |
| EP-3558309-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | UNIV VANDERBILT (US) | 2023-07-26 | — | — | EP | disclosed |
| EP-3558309-B1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | UNIV VANDERBILT (US) | 2023-07-26 | — | — | EP | disclosed |
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | VANDERBILT UNIVERSITY (US) | 2021-03-30 | — | — | US | disclosed |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-10-31 | — | — | US | disclosed |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | VANDERBILT UNIVERSITY | 2019-10-31 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10961253-B2 | Positive allosteric modulators of the muscarinic acetylcholine receptor M4 | CHRM2, CHRM4, CHRM5 | CHRM4 2/4885CDC7 3036/4885PLK4 2209/4885 |
| US-20190330225-A1 | POSITIVE ALLOSTERIC MODULATORS OF THE MUSCARINIC ACETYLCHOLINE RECEPTOR M4 | CHRM2, CHRM4, CHRM5 | CHRM4 2/4885CDC7 3036/4885PLK4 2209/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.