Sugi Predict

Sugi Predict / Compounds / SCHEMBL21528211

SCHEMBL21528211

SCHEMBL21528211

Clc1c(Br)cnc2[nH]c(CN3CCOCC3)cc12

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ CCNK O75909 1/20 0.48
▸ CDK12 Q9NYV4 1/20 0.48
▸ CYP2A13 Q16696 5/20 0.43
▸ FGFR1 P11362 2/20 0.42
▸ FGFR2 P21802 2/20 0.42
▸ FGFR3 P22607 2/20 0.42
▸ FGFR4 P22455 1/20 0.42
▸ AURKA O14965 4/20 0.41
▸ CHEK1 O14757 1/20 0.41
▸ ACHE P22303 1/20 0.41
▸ CSF1R P07333 1/20 0.40
▸ CNR1 P21554 1/20 0.39
▸ CNR2 P34972 1/20 0.39
▸ METAP2 P50579 1/20 0.37
▸ NPC1 O15118 1/20 0.37
▸ RAB9A P51151 1/20 0.37
▸ PAX8 Q06710 1/20 0.37
▸ L3MBTL1 Q9Y468 1/20 0.37
▸ HTT P42858 1/20 0.37
▸ HSD17B10 Q99714 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL20840003 0.80 CCNK (0.58) CCNKCDK12CYP2A13FGFR1FGFR2
SCHEMBL26686575 0.77 CCNK (0.58) CCNKCDK12CYP2A13CHEK1ACHE
SCHEMBL20536455 0.72 PDK2 (0.38) CCNKCDK12FGFR1
SCHEMBL16795049 0.70 CCNK (0.41) CCNKCDK12CYP2A13FGFR1FGFR2
SCHEMBL16794956 0.69 CCNK (0.47) CCNKCDK12CYP2A13CSF1RMETAP2
SCHEMBL27238725 0.69 CYP2A13 (0.50) CYP2A13CNR1CNR2METAP2NPC1
SCHEMBL4767556 0.68 EGFR (0.51) CSF1R
SCHEMBL29215986 0.67 EGFR (0.47) CYP2A13FGFR1AURKAMETAP2
SCHEMBL18376475 0.66 PIM1 (0.38) CCNKCDK12CYP2A13L3MBTL1HSD17B10
SCHEMBL18376429 0.66 HPGD (0.39) CCNKCDK12CYP2A13NPC1RAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 23 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-12552792-B2 Solid forms of an FGFR inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2026-02-17 — — US disclosed
US-20250276970-A1 DERIVATIVES OF AN FGFR INHIBITOR INCYTE CORPORATION 2025-09-04 — — US disclosed
CN-119241542-A Solid forms of FGFR inhibitors and methods of making the same 因赛特公司 2025-01-03 — — CN disclosed
CN-119241541-A Solid forms of FGFR inhibitors and methods of making the same 因赛特公司 2025-01-03 — — CN disclosed
CN-119241540-A Solid forms of FGFR inhibitors and methods of making the same 因赛特公司 2025-01-03 — — CN disclosed
US-20240425506-A1 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORPORATION 2024-12-26 — — US disclosed
US-12168660-B2 Derivatives of an FGFR inhibitor INCYTE CORPORATION (US) 2024-12-17 — — US disclosed
CN-112867716-B Solid forms of FGFR inhibitors and methods of making the same 因赛特公司 2024-09-13 — — CN disclosed
EP-3788047-B1 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME INCYTE CORP (US) 2024-09-04 — — EP disclosed
EP-4309737-A2 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME Incyte Corporation (US) 2024-01-24 — — EP disclosed
EP-4069695-A1 DERIVATIVES OF AN FGFR INHIBITOR Incyte Corporation (US) 2022-10-12 — — EP disclosed
US-11466004-B2 Solid forms of an FGFR inhibitor and processes for preparing the same INCYTE CORPORATION (US) 2022-10-11 — — US disclosed
CN-115151539-A Derivatives of FGFR inhibitors 因赛特公司 2022-10-04 — — CN disclosed
US-11407750-B2 Derivatives of an FGFR inhibitor INCYTE CORPORATION (US) 2022-08-09 — — US disclosed
US-20210171522-A1 DERIVATIVES OF AN FGFR INHIBITOR INCYTE CORPORATION 2021-06-10 — — US disclosed
WO-2021113462-A1 DERIVATIVES OF AN FGFR INHIBITOR INCYTE CORPORATION (US) 2021-06-10 — — WO disclosed
WO-2021113462-A1 DERIVATIVES OF AN FGFR INHIBITOR INCYTE CORPORATION (US) 2021-06-10 — — WO disclosed
CN-112867716-A Solid forms of FGFR inhibitors and methods for their preparation 因赛特公司 2021-05-28 — — CN disclosed
EP-3788047-A2 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME Incyte Corporation (US) 2021-03-10 — — EP disclosed
US-20190337948-A1 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME WILMINGTON PHARMATECH 2019-11-07 — — US disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (8 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20210171522-A1 DERIVATIVES OF AN FGFR INHIBITOR FGFR1, FGFR2, FGFR4 CCNK 597/4885CDK12 1020/4885CYP2A13 383/4885
US-20190337948-A1 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME FGFR1, FGFR2, FGFR3 CCNK 392/4885CDK12 683/4885CYP2A13 2424/4885
US-12168660-B2 Derivatives of an FGFR inhibitor FGFR1, FGFR2, FGFR4 CCNK 597/4885CDK12 1020/4885CYP2A13 383/4885
US-20240425506-A1 SOLID FORMS OF AN FGFR INHIBITOR AND PROCESSES FOR PREPARING THE SAME FGFR1, FGFR2, FGFR3 CCNK 392/4885CDK12 683/4885CYP2A13 2424/4885
US-20250276970-A1 DERIVATIVES OF AN FGFR INHIBITOR FGFR1, FGFR2, FGFR4 CCNK 597/4885CDK12 1020/4885CYP2A13 383/4885
US-11407750-B2 Derivatives of an FGFR inhibitor FGFR1, FGFR2, FGFR4 CCNK 597/4885CDK12 1020/4885CYP2A13 383/4885
US-12552792-B2 Solid forms of an FGFR inhibitor and processes for preparing the same FGFR2, FGFR1, FGF2 CCNK 381/4885CDK12 372/4885CYP2A13 2826/4885
US-11466004-B2 Solid forms of an FGFR inhibitor and processes for preparing the same FGFR1, FGFR2, FGFR3 CCNK 392/4885CDK12 683/4885CYP2A13 2424/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.

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