Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 12/20 | 0.70 |
| ▸ | CACNG8 | Q8WXS5 | 2/20 | 0.70 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.58 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.58 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.52 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.52 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.52 |
| ▸ | CRBN | Q96SW2 | 1/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.48 |
| ▸ | PGR | P06401 | 1/20 | 0.48 |
| ▸ | AHR | P35869 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189535 | 0.88 | GRIA1 (0.65) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL18189631 | 0.82 | GRIA1 (1.00) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL18189557 | 0.82 | GRIA1 (0.48) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL15730139 | 0.80 | GRIA1 (0.67) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL18189428 | 0.79 | GRIA1 (0.47) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL15344913 | 0.78 | PDE3B (0.58) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL23143522 | 0.77 | PDE3B (0.70) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL29899630 | 0.77 | PDE3B (0.70) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL18189476 | 0.77 | GRIA1 (0.82) | GRIA1CACNG8PDE3BPDE3ACYP1A2 | |
| SCHEMBL18189650 | 0.77 | GRIA1 (0.86) | GRIA1CACNG8PDE3BPDE3ACYP1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |