Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GRIA1 | P42261 | 9/20 | 0.45 |
| ▸ | CACNG8 | Q8WXS5 | 9/20 | 0.45 |
| ▸ | CACNG2 | Q9Y698 | 1/20 | 0.45 |
| ▸ | PBRM1 | Q86U86 | 4/20 | 0.34 |
| ▸ | AHR | P35869 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 2/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.33 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.33 |
| ▸ | SRC | P12931 | 1/20 | 0.33 |
| ▸ | PTGES | O14684 | 1/20 | 0.32 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18189394 | 0.83 | GRIA1 (0.60) | GRIA1CACNG8CACNG2AHRABL1 | |
| SCHEMBL18189528 | 0.77 | GRIA1 (0.69) | GRIA1CACNG8CACNG2AHRABL1 | |
| SCHEMBL18189551 | 0.73 | GRIA1 (0.55) | GRIA1CACNG8CACNG2AHRABL1 | |
| SCHEMBL18189587 | 0.72 | GRIA1 (0.54) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189650 | 0.69 | GRIA1 (0.86) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189309 | 0.69 | GRIA1 (0.50) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189602 | 0.69 | GRIA1 (0.56) | GRIA1CACNG8CACNG2AHRCYP1A2 | |
| SCHEMBL18189620 | 0.69 | GRIA1 (0.64) | GRIA1CACNG8CACNG2AHRABL1 | |
| SCHEMBL18189426 | 0.67 | GRIA1 (0.46) | GRIA1CACNG8CACNG2AHRABL1 | |
| SCHEMBL18189530 | 0.67 | GRIA1 (0.69) | GRIA1CACNG8CACNG2AHRPTGES |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3288935-B1 | INDOLONE COMPOUNDS AND THEIR USE AS AMPA RECEPTOR MODULATORS | JANSSEN PHARMACEUTICA NV (BE) | 2019-10-30 | — | — | EP | disclosed |