Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK3 | P52333 | 7/20 | 0.62 |
| ▸ | JAK2 | O60674 | 4/20 | 0.50 |
| ▸ | JAK1 | P23458 | 4/20 | 0.50 |
| ▸ | TYK2 | P29597 | 4/20 | 0.50 |
| ▸ | AKT2 | P31751 | 11/20 | 0.49 |
| ▸ | GSK3B | P49841 | 3/20 | 0.49 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.49 |
| ▸ | AKT1 | P31749 | 2/20 | 0.49 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.49 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.49 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.45 |
| ▸ | AKT3 | Q9Y243 | 1/20 | 0.45 |
| ▸ | HTR2C | P28335 | 1/20 | 0.45 |
| ▸ | KIT | P10721 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21538581 | 0.81 | JAK3 (0.90) | JAK3JAK2JAK1TYK2AKT2 | |
| SCHEMBL1048640 | 0.79 | JAK3 (0.83) | JAK3JAK2JAK1TYK2AKT2 | |
| SCHEMBL318828 | 0.78 | JAK3 (0.86) | JAK3JAK2JAK1TYK2 | |
| SCHEMBL323138 | 0.77 | JAK3 (0.76) | JAK3AKT2GSK3BCYP2C9AKT1 | |
| SCHEMBL10206821 | 0.77 | JAK3 (1.00) | JAK3JAK2 | |
| SCHEMBL21518338 | 0.74 | JAK3 (0.66) | JAK3JAK2JAK1TYK2AKT2 | |
| SCHEMBL322327 | 0.74 | JAK3 (0.63) | JAK3JAK2JAK1TYK2AKT2 | |
| SCHEMBL2048915 | 0.69 | AKT2 (0.70) | JAK3JAK2JAK1TYK2AKT2 | |
| SCHEMBL1002738 | 0.69 | AKT2 (0.77) | AKT2GSK3BCYP2C9AKT1CYP2D6 | |
| SCHEMBL1789204 | 0.68 | RPS6KB1 (0.72) | JAK3AKT2GSK3BAKT1RPS6KB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560932-A1 | METHOD FOR PRODUCING 7H-PYRROLO[2,3-D]PYRIMIDINE DERIVATIVE AND SYNTHETIC INTERMEDIATE OF SAME | Japan Tobacco, Inc. (JP) | 2019-10-30 | — | — | EP | disclosed |