Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Leucine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC7A5 | Q01650 | 1/20 | 0.82 |
| ▸ | SLC1A3 | P43003 | 7/20 | 0.63 |
| ▸ | SLC1A2 | P43004 | 7/20 | 0.63 |
| ▸ | SLC1A1 | P43005 | 7/20 | 0.54 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.47 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.47 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.47 |
| ▸ | PGR | P06401 | 1/20 | 0.47 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.47 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.46 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.46 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.46 |
| ▸ | GRIK1 | P39086 | 5/20 | 0.45 |
| ▸ | GRIK2 | Q13002 | 3/20 | 0.45 |
| ▸ | GRIA2 | P42262 | 3/20 | 0.43 |
| ▸ | GRIA4 | P48058 | 3/20 | 0.43 |
| ▸ | GRIK3 | Q13003 | 3/20 | 0.43 |
| ▸ | GRIK5 | Q16478 | 3/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Leucine SCHEMBL11046762 | 1.00 | SLC7A5 (0.82) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| D-Leucine SCHEMBL18114536 | 1.00 | SLC7A5 (0.82) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL4639771 | 1.00 | SLC7A5 (0.82) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL678117 | 1.00 | SLC7A5 (0.82) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL625031 | 1.00 | SLC7A5 (0.82) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| D-Leucine SCHEMBL1537345 | 1.00 | SLC7A5 (0.82) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL4664449 | 0.96 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL4946381 | 0.96 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL3049775 | 0.96 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 | |
| Leucine SCHEMBL4394541 | 0.96 | SLC7A5 (0.75) | SLC7A5SLC1A3SLC1A2SLC1A1CACNA2D1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 31 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3560509-B1 | SAPOSIN-A DERIVED PEPTIDES AND USES THEREOF | CHILDRENS MEDICAL CENTER (US) | 2024-01-31 | — | — | EP | claimed |
| CN-109701007-A | A kind of nontoxicity Sequencing of Beta Toxin Gene of Clostridium perfringens engineered vaccine and its production method | 中国兽医药品监察所 | 2019-05-03 | — | — | CN | claimed |
| EP-2793921-B1 | SAPOSIN-A DERIVED PEPTIDES AND USES THEREOF | CHILDRENS MEDICAL CENTER (US) | 2019-04-24 | — | — | EP | claimed |
| CN-102516382-B | Antimicrobial peptide Hainanenin-5 of Amolops hainanensis, gene of antimicrobial peptide Hainanenin-5 of Amolops hainanensis, and application of gene of antimicrobial peptide Hainanenin-5 of Amolops hainanensis | UNIV DALIAN TECH | 2014-04-16 | — | — | CN | claimed |
| EP-2519101-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | Kempharm, Inc. (US) | 2012-11-07 | — | — | EP | claimed |
| WO-2011082076-A1 | AMINO ACID CONJUGATES OF QUETIAPINE, PROCESS FOR MAKING AND USING THE SAME | KEMPHARM, INC. (US) | 2011-07-07 | — | — | WO | claimed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | claimed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | claimed |
| CN-109804311-B | Chemically amplified positive photoresist composition and pattern forming method using the same | 默克专利有限公司 | 2023-06-06 | — | — | CN | disclosed |
| CN-109966502-B | Composition for improving solubility of poorly soluble substance, use thereof, and complex preparation containing same | 财团法人工业技术研究院 | 2023-01-24 | — | — | CN | disclosed |
| US-11364279-B2 | Medicament used for treating hypertension | Shandong Zhonghai Pharmaceutical CO. LTD (CN) | 2022-06-21 | — | — | US | disclosed |
| WO-2021106107-A1 | MATERIAL AND COLUMN FOR COLLECTING CELLS HAVING RECOVERY FUNCTION OF HYPO-IMMUNE STATE | 国立大学法人滋賀医科大学 | 2021-06-03 | — | — | WO | disclosed |
| US-10993976-B2 | Medicament for treating uremia and proteinuria | Shandong Zhonghai Pharmaceutical CO. LTD (CN) | 2021-05-04 | — | — | US | disclosed |
| EP-3630142-A1 | EXTRACTS FROM ARTHROSPIRA AND USES THEREOF | Biovite Australia Pty Ltd (AU) | 2020-04-08 | — | — | EP | disclosed |
| CN-101836692-B | Amino acid biological fish fertilizer and preparation method thereof | WUHAN HONGSHAN LVDUN AMINO ACID PLANT | 2012-11-21 | — | — | CN | disclosed |
| CN-101836692-A | Amino acid biological fish fertilizer and preparation method thereof | WUHAN HONGSHAN LVDUN AMINO ACID PLANT | 2010-09-22 | — | — | CN | disclosed |
| CN-1151761-A | Subtilisin BPN' variants with reduced adsorption and increased hydrolysis | PROCTER & GAMBLE (US) | 1997-06-11 | — | — | CN | disclosed |
| EP-0368920-A1 | LECTINES FIXING BETA-D-GALACTOSIDE. | IDEON CORP (US) | 1990-05-23 | — | — | EP | disclosed |
| WO-1989000581-A1 | LECTINES FIXING BETA-D-GALACTOSIDE | IDEON CORPORATION (US) | 1989-01-26 | — | — | WO | disclosed |
| US-4535167-A | CONDENSATION OF ACID AND ALDEHYDE FOLLOWED BY REDUCTIVE CLEAVAGE OF OXAZOLIDINONE INTERMEDIATE | MERCK & CO. INC. (US) | 1985-08-13 | — | — | US | disclosed |