Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RECQL | P46063 | 1/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.43 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 3/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.41 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.40 |
| ▸ | THRB | P10828 | 2/20 | 0.40 |
| ▸ | USP30 | Q70CQ3 | 1/20 | 0.39 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2154252 | 1.00 | RECQL (0.49) | RECQLUSP2SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL14681442 | 0.92 | SMN1; SMN2 (0.51) | RECQLUSP2SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL77972 | 0.85 | RECQL (0.56) | RECQLUSP2SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL14681648 | 0.84 | SMN1; SMN2 (0.54) | RECQLUSP2SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL13107602 | 0.81 | PRMT5 (0.46) | RECQLPRMT5WDR77PIK3CDUSP30 | |
| SCHEMBL28684525 | 0.81 | PRMT5 (0.46) | RECQLUSP2SMN1; SMN2PRMT5WDR77 | |
| SCHEMBL21777218 | 0.79 | PRMT5 (0.44) | RECQLPRMT5WDR77PIK3CDUSP30 | |
| SCHEMBL21767695 | 0.79 | PRMT5 (0.44) | RECQLPRMT5WDR77PIK3CDUSP30 | |
| SCHEMBL21767794 | 0.79 | PRMT5 (0.44) | RECQLPRMT5WDR77PIK3CDUSP30 | |
| SCHEMBL21767696 | 0.79 | PRMT5 (0.44) | RECQLPRMT5WDR77PIK3CDUSP30 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2011088045-A1 | AURORA KINASE COMPOUNDS AND METHODS OF THEIR USE | AMBIT BIOSCIENCES CORPORATION (US) | 2011-07-21 | — | — | WO | disclosed |