Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IDO1 | P14902 | 2/20 | 0.38 |
| ▸ | PTGDR | Q13258 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.37 |
| ▸ | HTT | P42858 | 3/20 | 0.37 |
| ▸ | CNR1 | P21554 | 1/20 | 0.36 |
| ▸ | CNR2 | P34972 | 1/20 | 0.36 |
| ▸ | HPGD | P15428 | 3/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TP53 | P04637 | 2/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 1/20 | 0.35 |
| ▸ | XBP1 | P17861 | 1/20 | 0.35 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.35 |
| ▸ | DPP4 | P27487 | 1/20 | 0.35 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21526062 | 0.92 | HPGD (0.38) | IDO1PTGDRSMN1; SMN2HTTCNR1 | |
| SCHEMBL21526087 | 0.78 | HPGD (0.39) | PTGDRSMN1; SMN2HTTHPGDNPSR1 | |
| SCHEMBL21526097 | 0.77 | HPGD (0.42) | IDO1SMN1; SMN2HTTCNR1CNR2 | |
| SCHEMBL21526117 | 0.76 | SMN1; SMN2 (0.44) | IDO1SMN1; SMN2HTTCNR1CNR2 | |
| SCHEMBL21548808 | 0.76 | HPGD (0.39) | IDO1SMN1; SMN2HTTCNR1CNR2 | |
| SCHEMBL21526130 | 0.75 | SMN1; SMN2 (0.38) | IDO1SMN1; SMN2HTTCNR1CNR2 | |
| SCHEMBL21548938 | 0.73 | SMN1; SMN2 (0.39) | IDO1SMN1; SMN2HTTCNR1CNR2 | |
| SCHEMBL21548932 | 0.72 | MAPT (0.43) | SMN1; SMN2HPGDNPSR1ALDH1A1TP53 | |
| SCHEMBL21526141 | 0.69 | SMN1; SMN2 (0.49) | SMN1; SMN2HTTHPGDNPSR1ALDH1A1 | |
| SCHEMBL21526137 | 0.67 | SMN1; SMN2 (0.41) | PTGDRSMN1; SMN2HTTHPGDNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3564216-A1 | PYRIMIDINE DERIVATIVE | DAIICHI SANKYO COMPANY, LIMITED (JP) | 2019-11-06 | — | — | EP | disclosed |