Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 1/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 2/20 | 0.33 |
| ▸ | BLM | P54132 | 2/20 | 0.33 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.33 |
| ▸ | TSHR | P16473 | 1/20 | 0.33 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | THRB | P10828 | 1/20 | 0.33 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | BTK | Q06187 | 1/20 | 0.33 |
| ▸ | GAA | P10253 | 1/20 | 0.32 |
| ▸ | EGLN1 | Q9GZT9 | 1/20 | 0.31 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.30 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.30 |
| ▸ | RELA | Q04206 | 1/20 | 0.30 |
| ▸ | POLB | P06746 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2155877 | 0.82 | MAPK1 (0.33) | MAPK1CYP2D6LMNABLMALOX15 | |
| SCHEMBL19520662 | 0.79 | MAPK1 (0.41) | MAPK1THRBGAANFKB1NFKB2 | |
| SCHEMBL3570843 | 0.75 | MAPT (0.43) | MAPK1LMNATSHRMEN1KMT2A | |
| SCHEMBL2218168 | 0.75 | MAPT (0.43) | MAPK1LMNATSHRMEN1KMT2A | |
| SCHEMBL29599645 | 0.75 | MAPT (0.43) | MAPK1LMNATSHRMEN1KMT2A | |
| SCHEMBL1325536 | 0.75 | MAPT (0.43) | MAPK1LMNATSHRMEN1KMT2A | |
| SCHEMBL2216604 | 0.75 | MAPT (0.43) | MAPK1LMNATSHRMEN1KMT2A | |
| SCHEMBL8120909 | 0.75 | MAPT (0.43) | MAPK1LMNATSHRMEN1KMT2A | |
| SCHEMBL9356138 | 0.73 | CYP2D6 (0.56) | MAPK1CYP2D6LMNABLMALOX15 | |
| SCHEMBL9356321 | 0.73 | CYP2D6 (0.56) | MAPK1CYP2D6LMNABLMALOX15 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2861581-A1 | IAP ANTAGONISTS | Bristol-Myers Squibb Company (US) | 2015-04-22 | — | — | EP | disclosed |
| WO-2013192286-A1 | IAP ANTAGONISTS | BRISTOL-MYERS SQUIBB COMPANY (US) | 2013-12-27 | — | — | WO | disclosed |
| WO-2013052369-A1 | NOVEL BENZIMIDAZOLE DERIVATIVES | ENANTA PHARMACEUTICALS, INC. (US) | 2013-04-11 | — | — | WO | disclosed |
| EP-2512480-A1 | HEPATITIS C VIRUS INHIBITORS | Enanta Pharmaceuticals, Inc. (US) | 2012-10-24 | — | — | EP | disclosed |
| WO-2011081918-A1 | HEPATITIS C VIRUS INHIBITORS | ENANTA PHARMACEUTICALS, INC (US) | 2011-07-07 | — | — | WO | disclosed |