Predicted protein targets (top 2)
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21554266 | 0.94 | MKNK2 (0.76) | MKNK2MKNK1 | |
| SCHEMBL21554334 | 0.94 | MKNK1 (0.66) | MKNK2MKNK1 | |
| SCHEMBL21554301 | 0.86 | MKNK2 (0.89) | MKNK2MKNK1 | |
| SCHEMBL21554270 | 0.85 | MKNK1 (0.70) | MKNK2MKNK1 | |
| SCHEMBL21554281 | 0.81 | MKNK1 (0.74) | MKNK2MKNK1 | |
| SCHEMBL22722390 | 0.81 | MKNK1 (0.74) | MKNK2MKNK1 | |
| SCHEMBL20479143 | 0.81 | MKNK1 (0.74) | MKNK2MKNK1 | |
| SCHEMBL22722382 | 0.81 | MKNK1 (0.74) | MKNK2MKNK1 | |
| SCHEMBL21554508 | 0.81 | MKNK1 (0.64) | MKNK2MKNK1 | |
| SCHEMBL21554336 | 0.81 | MKNK1 (0.64) | MKNK2MKNK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-10851082-B2 | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) | NORTHWESTERN UNIVERSITY (US) | 2020-12-01 | — | — | US | disclosed |
| EP-3564235-A1 | SUBSTITUTED AROMATIC N-HETEROCYCLIC COMPOUNDS AS INHIBITORS OF MITOGEN-ACTIVATED PROTEIN KINASE INTERACTING KINASE 1 (MNK1) AND 2 (MNK2) | Northwestern University (US) | 2019-11-06 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-10851082-B2 | Substituted aromatic n-heterocyclic compounds as inhibitors of mitogen-activated protein kinase interacting kinase 1 (MNK1) and 2 (MNK2) | MAP4K2, MAP3K20, MKNK2 | MKNK2 3/4885MKNK1 5/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.