Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK4 | P11802 | 17/20 | 0.80 |
| ▸ | CDK1 | P06493 | 5/20 | 0.80 |
| ▸ | CDK2 | P24941 | 3/20 | 0.80 |
| ▸ | CCND3 | P30281 | 3/20 | 0.79 |
| ▸ | GAK | O14976 | 1/20 | 0.79 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.79 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.79 |
| ▸ | FECH | P22830 | 1/20 | 0.79 |
| ▸ | CCND1 | P24385 | 1/20 | 0.79 |
| ▸ | CDK9 | P50750 | 1/20 | 0.79 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.79 |
| ▸ | CDK16 | Q00536 | 1/20 | 0.79 |
| ▸ | MAP3K1 | Q13233 | 1/20 | 0.79 |
| ▸ | CAMK2G | Q13555 | 1/20 | 0.79 |
| ▸ | CAMK2D | Q13557 | 1/20 | 0.79 |
| ▸ | Q6ZSR9 | Q6ZSR9 | 1/20 | 0.79 |
| ▸ | PRKD2 | Q9BZL6 | 1/20 | 0.79 |
| ▸ | SIK2 | Q9H0K1 | 1/20 | 0.79 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.70 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL22600074 | 0.94 | CDK4 (0.78) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL21036418 | 0.91 | CDK4 (0.85) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL302331 | 0.91 | CDK4 (0.89) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL30176525 | 0.91 | CDK4 (0.89) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL21227657 | 0.91 | CDK4 (0.86) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL19986419 | 0.90 | CDK4 (0.82) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL28021325 | 0.90 | CDK4 (0.74) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL22616331 | 0.90 | CDK4 (0.74) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL2684165 | 0.89 | CDK4 (0.81) | CDK4CDK1CDK2CCND3GAK | |
| SCHEMBL1999434 | 0.89 | CDK4 (0.81) | CDK4CDK1CDK2CCND3GAK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-11541051-B2 | Compositions and methods for treating CDK4/6-mediated cancer | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI (US) | 2023-01-03 | — | — | US | disclosed |
| US-20210338670-A1 | NON-INVASIVE PET IMAGING OF CDK4/6 ACTIVATION IN CANCER | NEW YORK UNIVERSITY | 2021-11-04 | — | — | US | disclosed |
| US-11040106-B2 | Conjugates of kinase inhibitors and cyanine dyes | Small Molecule PPI Mimics LLC (US) | 2021-06-22 | — | — | US | disclosed |
| US-20200339572-A1 | NOVEL SELECTIVE CDK4/6 INHIBITOR AND PREPARATION THEREOF | WUXI SHUANGLIANG BIOTECHNOLOGY CO., LTD. (CN) | 2020-10-29 | — | — | US | disclosed |
| US-20190343958-A1 | CONJUGATES OF KINASE INHIBITORS AND CYANINE DYES | UNITED STATES GOVERNMENT | 2019-11-14 | — | — | US | disclosed |
| US-20190336503-A1 | COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER | ICAHN SCHOOL OF MEDICINE AT MOUNT SINAI | 2019-11-07 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (6 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20210338670-A1 | NON-INVASIVE PET IMAGING OF CDK4/6 ACTIVATION IN CANCER | CDK4, CDK6, CDKL4 | CDK4 1/4885CDK1 9/4885CDK2 7/4885 |
| US-11040106-B2 | Conjugates of kinase inhibitors and cyanine dyes | ABL1, MAP3K20, MAP4K2 | CDK4 324/4885CDK1 105/4885CDK2 108/4885 |
| US-20190336503-A1 | COMPOSITIONS AND METHODS FOR TREATING CDK4/6-MEDIATED CANCER | CDK4, CDK6, CDK2 | CDK4 1/4885CDK1 11/4885CDK2 3/4885 |
| US-20190343958-A1 | CONJUGATES OF KINASE INHIBITORS AND CYANINE DYES | ABL1, MAP3K20, MAP4K2 | CDK4 324/4885CDK1 105/4885CDK2 108/4885 |
| US-20200339572-A1 | NOVEL SELECTIVE CDK4/6 INHIBITOR AND PREPARATION THEREOF | CDK4, CDK6, CCNI | CDK4 1/4885CDK1 7/4885CDK2 12/4885 |
| US-11541051-B2 | Compositions and methods for treating CDK4/6-mediated cancer | CDK4, CDK6, CDK2 | CDK4 1/4885CDK1 11/4885CDK2 3/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.