Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR3 | P22607 | 15/20 | 0.69 |
| ▸ | KDR | P35968 | 15/20 | 0.69 |
| ▸ | FGFR1 | P11362 | 13/20 | 0.43 |
| ▸ | FGFR2 | P21802 | 13/20 | 0.43 |
| ▸ | FGFR4 | P22455 | 13/20 | 0.43 |
| ▸ | FLT3 | P36888 | 4/20 | 0.43 |
| ▸ | CSF1R | P07333 | 2/20 | 0.43 |
| ▸ | KIT | P10721 | 1/20 | 0.42 |
| ▸ | APP | P05067 | 1/20 | 0.41 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.41 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.41 |
| ▸ | YES1 | P07947 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19749646 | 0.86 | FGFR3 (0.66) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL21554939 | 0.85 | FGFR3 (0.65) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL12178203 | 0.83 | FGFR3 (0.76) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL16421990 | 0.82 | FGFR3 (0.65) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL12178236 | 0.81 | FGFR3 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL29870618 | 0.81 | FGFR3 (1.00) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL19749883 | 0.78 | FGFR3 (0.74) | FGFR3KDRFGFR1FGFR2FGFR4 | |
| SCHEMBL22122109 | 0.78 | KDR (0.59) | FGFR3KDRCSF1RKITPDGFRB | |
| SCHEMBL14788087 | 0.78 | KDR (0.59) | FGFR3KDRFGFR1CSF1RKIT | |
| SCHEMBL28634926 | 0.78 | KDR (0.59) | FGFR3KDRFGFR1FGFR2FGFR4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2776408-B1 | ANTICANCER BENZOPYRAZINES VIA THE INHIBITION OF FGFR KINASES | ASTEX THERAPEUTICS LTD (GB) | 2019-11-06 | — | — | EP | disclosed |